There is an error in the first row of Table 3. Please see the correct Table 3 here.
Table 3. Complete list of point mutations among the genes sequenced in the 37 HNSCC tissues.
| # | Gene Symbol | AA COSMIC | Chromosome | Position | Reference Base | Alternate Base | Effect | CDS Change | Prior AA Reports | Sample ID |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CDH1 | p.G382D | 16 | 68847223 | G | A | NON_SYNONYMOUS | gGt/gAt | None | X13 |
| 2 | CDKN2A | p.G130V | 9 | 21971012 | C | A | NON_SYNONYMOUS | gGa/gTa | None | X1 |
| 3 | CEBPA | p.R323G | 19 | 33792354 | G | C | NON_SYNONYMOUS | Cgc/Ggc | None | X15 |
| 4 | FES | p.S96L | 15 | 91428715 | C | T | NON_SYNONYMOUS | tCa/tTa | None | X33 |
| 5 | FGFR3 | p.K652N | 4 | 1807891 | G | T | NON_SYNONYMOUS | aaG/aaT | None | X21 |
| 6 | FGFR3 | p.S249C | 4 | 1803568 | C | G | NON_SYNONYMOUS | tCc/tGc | Yes | X20 |
| 7 | FLT3 | p.F590L | 13 | 28608286 | G | C | NON_SYNONYMOUS | ttC/ttG | None | X25 |
| 8 | MPL | p.L500V | 1 | 43814963 | C | G | NON_SYNONYMOUS | Cta/Gta | None | X35 |
| 9 | NOTCH1 | p.E1294* | 9 | 139401189 | C | A | STOP_GAINED | Gag/Tag | None | X35 |
| 10 | NOTCH1 | p.R56* | 9 | 139418406 | G | A | STOP_GAINED | Cga/Tga | None | X28 |
| 11 | NOTCH1 | p.W1843* | 9 | 139396309 | C | T | STOP_GAINED | tgG/tgA | Yes | X11 |
| 12 | PIK3CA | p.E545K | 3 | 178936091 | G | A | NON_SYNONYMOUS | Gag/Aag | Yes | X25 |
| 13 | PIK3R1 | p.M26I | 5 | 67588148 | G | A | NON_SYNONYMOUS | atG/atA | None | X13 |
| 14 | TP53 | p.C135F | 17 | 7578526 | C | A | NON_SYNONYMOUS | tGc/tTc | Yes | X1 |
| 15 | TP53 | p.R175H | 17 | 7578406 | C | T | NON_SYNONYMOUS | cGc/cAc | Yes | X27 |
| 16 | TP53 | p.C176Y | 17 | 7578403 | C | T | NON_SYNONYMOUS | tGc/tAc | Yes | X4 |
| 17 | TP53 | p.H179R | 17 | 7578394 | T | C | NON_SYNONYMOUS | cAt/cGt | Yes | X33 |
| 18 | TP53 | p.Y220C | 17 | 7578190 | T | C | NON_SYNONYMOUS | tAt/tGt | Yes | X5 |
| 19 | TP53 | p.Y234N | 17 | 7577581 | A | T | NON_SYNONYMOUS | Tac/Aac | Yes | X16 |
| 20 | TP53 | p.Y234S | 17 | 7577580 | T | G | NON_SYNONYMOUS | tAc/tCc | Yes | X12 |
| 21 | TP53 | p.S241F | 17 | 7577559 | G | A | NON_SYNONYMOUS | tCc/tTc | Yes | X16 |
| 22 | TP53 | p.R248Q | 17 | 7577538 | C | T | NON_SYNONYMOUS | cGg/cAg | Yes | X34 |
| 23 | TP53 | p.R273C | 17 | 7577121 | G | A | NON_SYNONYMOUS | Cgt/Tgt | Yes | X28 |
| 24 | TP53 | p.R282W | 17 | 7577094 | G | A | NON_SYNONYMOUS | Cgg/Tgg | Yes | X23 |
| 25 | TP53 | p.Q317* | 17 | 7576897 | G | A | STOP_GAINED | Cag/Tag | Yes | X35 |
| 26 | TP53 | p.R342* | 17 | 7574003 | G | A | STOP_GAINED | Cga/Tga | Yes | X27 |
Reference
- 1.Gaykalova DA, Mambo E, Choudhary A, Houghton J, Buddavarapu K, Sanford T, et al. (2014) Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma. PLoS ONE 9(3): e93102 10.1371/journal.pone.0093102 [DOI] [PMC free article] [PubMed] [Google Scholar]