Table 1.

The most significantly enriched pathways in the four different sets of deregulated miRNAs. The top ten pathways with the highest p-values are listed for each dataset.

KEGG Pathway	p-Value
plasma: MDS vs. CTR
Mucin type O-Glycan biosynthesis	9.77 × 10−15
Proteoglycans in cancer	6.05 × 10−9
ErbB signaling pathway	2.80 × 10−8
Ras signaling pathway	2.02 × 10−7
Axon guidance	2.02 × 10−5
Pathways in cancer	2.02 × 10−5
Rap1 signaling pathway	3.30 × 10−5
Lysine degradation	3.33 × 10−5
Glioma	6.23 × 10−5
Signaling pathways regulating pluripotency of stem cells	9.51 × 10−5
EVs: MDS vs. CTR
ECM-receptor interaction	1.16 × 10−26
Fatty acid biosynthesis	1.41 × 10−8
ErbB signaling pathway	1.41 × 10−8
Proteoglycans in cancer	1.57 × 10−8
Axon guidance	3.54 × 10−8
Glioma	5.42 × 10−8
Mucin type O-Glycan biosynthesis	5.18 × 10−6
Estrogen signaling pathway	3.52 × 10−5
Focal adhesion	5.71 × 10−5
Signaling pathways regulating pluripotency of stem cells	5.71 × 10−5
plasma: early vs. advanced MDS
Amphetamine addiction	1.56 × 10−7
Signaling pathways regulating pluripotency of stem cells	5.60 × 10−6
Transcriptional misregulation in cancer	1.35 × 10−5
Gap junction	2.31 × 10−5
Glioma	3.38 × 10−5
FoxO signaling pathway	5.34 × 10−5
Hippo signaling pathway	1.16 × 10−4
ErbB signaling pathway	1.72 × 10−4
Proteoglycans in cancer	1.75 × 10−4
TGF-beta signaling pathway	2.54 × 10−4
EVs: early vs. advanced MDS
Biotin metabolism	7.16 × 10−3
Central carbon metabolism in cancer	7.16 × 10−3
Signaling pathways regulating pluripotency of stem cells	7.16 × 10−3
Lysine degradation	9.83 × 10−3
TGF-beta signaling pathway	9.83 × 10−3
Steroid biosynthesis	1.29 × 10−2
Glioma	1.39 × 10−2
RNA transport	1.41 × 10−2
ErbB signaling pathway	1.45 × 10−2
Morphine addiction	1.45 × 10−2