Figure 7.

NNK promotes cell viability in lung (NCI) and head and neck (FaDu) squamous cancer cells, which is prevented by miR-21 inhibition. Graphs depict the viability rates in (A) NCI and (B) FaDu exposed to 1 μM and 2 μM of NNK (% of viable cells in NNK groups vs untreated controls) and the changes in the viability of (C) NCI and (D) FaDu cells under the inhibition of miR-21 (miR21-inh). Graphs, created by GraphPad Prism 7 software; ** p < 0.005; *** p < 0.0005; **** p < 0.00005; ***** p < 0.000005, by t-test; multiple comparisons by Holm-Sidak). (Data are derived from three independent experiments.).