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Monocarboxylate transporter (MCT) inhibition reverted the lactate-derived EMT effect in RCC and normal kidney cell lines. Characterization of N-cadherin expression after CHC treatment in (A) RCC cell lines and (B) normal kidney cell line, by Western blot. N-cadherin, SMAD4, and SNAIL expression in HKC8 cell lines after CHC tumor cell line-derived CM treatment (C). Abbreviations: CTR—control, CHC—alpha-cyano-4-hydroxycinnamate, CM—conditioned medium, LAC—20 mM lactate, NCAD—N-cadherin.
