Table 1.
Sporadic inclusion body myositis (IBM) patient characteristics.
| Patient | Gender/Age | Clinical Features | Muscle Pathology | Autoantibodies |
|---|---|---|---|---|
| IBM1 | M/63 | Forearm, finger, and quadriceps weakness. | Several non-necrotic invaded fibers and fibers with rimmed vacuoles and inclusions. | cNIA+ |
| IBM2 | M/71 | Forearm and finger flexor weakness. | Several muscle fibers with rimmed vacuoles and inclusions, rare inflammation. | cNIA- |
| IBM3 | M/72 | Forearm, finger, and quadriceps weakness. | Some fibers with rimmed vacuoles and with inclusions. | cNIA- |
| IBM4 | M/70 | Quadriceps muscle weakness. | Severe inflammation and fibrosis, many fibers with inclusions. | ND |
| IBM5 | M/65 | Forearm flexor and quadriceps weakness. | Severe inflammation, many fibers with inclusions. | ND |
| IBM6 | F/59 | Proximal leg and distal finger flexor muscle weakness. | Many non-necrotic invaded fibers, some fibers with inclusions, mild fibrosis. | ND |
| IBM7 | M/83 | Forearm flexor and quadriceps weakness. | Several non-necrotic invaded fibers and fibers with rimmed vacuoles and inclusions. | cNIA- |
| IBM8 | F/59 | Dysphagia, forearm finger flexor, and quadriceps weakness. | Rare non-necrotic invaded fibers, few inclusions, mild fibrosis. | cNIA- |
| IBM9 | M/72 | Quadriceps muscle weakness. | Many fibers with rimmed vacuoles and inclusions, scarce inflammation. | cNIA+ |
cytosolic 5′-nucleotidase 1A autoantibody seropositive (cNIA+); seronegative (cNIA-); not determined (ND).