Figure 1.

Allicin Reduces Adiposity and Improves Glucose Homeostasis in DIO Mice

Vehicle (control) or different doses of allicin were administrated each day for a total of 13 weeks.

(A) Body weight evaluation of control HFD mice or mice treated with different doses of allicin. (n = 9).

(B) Body weight again of different groups of mice (n = 9).

(C) Body fat percentage test using nuclear magnetic resonance.

(D) Organ weight of control and allicin-treated HFD mice (n = 6).

(E) H&E staining of BAT, sWAT, and eWAT sections from DIO control and allicin-treated DIO mice. Scale bars, 100 μm.

(F) Quantification of the area of adipocytes in the selection of H&E sections in (E).

(G and H) (G) Glucose tolerance test of control and allicin-treated DIO mice (intraperitoneally with glucose as 1.0 g/kg after 16-h fast) (n = 8). (H) The average area under the curve (n = 8).

(I and J) (I) Insulin tolerance test was performed on control and allicin-treated DIO mice (injection insulin with 2.0 U/kg after 6 h of fasting (n = 8). (J) The average area under the curve (n = 8).

Values represent means ± SEM. Error bars represent SEM; significant differences compared with vehicle controls are indicated by ∗p < 0.05, ∗∗p < 0.01(assessed by Student's t test). Different letters indicate signicance among groups (P<0.05).