Figure 8. Pkd2 ecKO elevates systemic blood pressure, but does not alter cardiac function or kidney histology.
(A) Mean diastolic and systolic blood pressures in Pkd2fl/fl and Pkd2 ecKO mice (n = 5 for each). * indicates p<0.05 versus Pkd2fl/fl. (B) Mean arterial blood pressure (MAP) (n = 5 for each). * indicates p<0.05 versus Pkd2fl/fl. (C–F) Mean echocardiography data. Heart rate (HR), Cardiac output (CO), fractional shortening (FS) and ejection fraction (EF) (n = 5 Pkd2fl/fl and n = 10 for Pkd2 ecKO). (G) Representative images of H and E stained kidney cortex used for histological assessment. Scale bars = 100 µm. (H) Mean proximal tubule length (n = 15 proximal tubules measured for each group from three individual mice). (I) Mean glomeruli surface area (n = 75 glomeruli measured per group from three individual mice).
Figure 8—figure supplement 1. Locomotion is similar in Pkd2fl/fl and Pkd2 ecKO mice (n = 5 for each).
