Table 1.
The capacity of Bacteroides and Parabacteroides isolates to attenuate lipopolysaccharide (LPS)-induced IL-8 release from HT-29 cell line.
| Isolate | Significant IL-8 Decrease */ Total Number of Attenuation Experiments |
% Decrease in IL-8 Release as Compared to the LPS Control |
Attenuation Competence # |
|---|---|---|---|
| Pd1 | 1/4 | 7–53 | - |
| Pd2 | 4/5 | 35–61 | + |
| Pd3 | 3/3 | 27–39 | + |
| Pd4 | 4/6 | 23–59 | + |
| Pd5 | 0/3 | 0–11 | - |
| Pd6 | 0/3 | 15–23 | - |
| Bc1 | 4/6 | 12–44 | + |
| Bc2 | 3/4 | 21–46 | + |
| Bc3 | 3/5 | 33–48 | + |
| Bf | 0/3 | 1–34 | - |
| Bi1 | 3/3 | 21–72 | + |
| Bi2 | 3/4 | 25–66 | + |
| Bi3 | 3/4 | 27–51 | + |
| Bu | 4/6 | 34–59 | + |
| Bv1 | 3/4 | 26–39 | + |
| Bv2 | 3/3 | 23–36 | + |
| Bv3 | 5/9 | 39–59 | + |
| Bv4 | 3/3 | 25–40 | + |
| Bv5 | 3/3 | 41–55 | + |
| Bo1 | 2/5 | 5–58 | - |
| Bo2 | 4/8 | 0–39 | - |
| Bo3 | 4/6 | 30–50 | + |
| Bo4 | 3/4 | 35–57 | + |
| Bo5 | 3/7 | 0–39 | - |
| Bo6 | 0/3 | 17–26 | - |
| Bo7 | 3/7 | 0–28 | - |
| Bo8 | 2/5 | 0–54 | - |
| Bo9 | 1/5 | 0–45 | - |
* Significant (p < 0.05) decrease in IL-8 release as compared to the control, i.e., LPS stimulation without a prior exposure to the studied isolate. #no attenuation or seldomly detected (−), attenuation constantly detected (+). Pd = P. distasonis, Bc = B. caccae, Bf = B. fragilis, Bi = B. intestinalis, Bu = B. uniformis, Bv = B. vulgatus, Bo = B. ovatus. Numbers 1–9 refer to the specific isolate. # Isolates that significantly (p ≤ 0.05) decreased IL-8 release in at least three independent experiments and in majority of experiments were considered to have attenuation competence (+).