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. 2020 Mar 31;12(4):382. doi: 10.3390/v12040382

Figure 3.

Figure 3

Host SAMHD1 restricts HIV-1 infection within macrophages at the reverse transcription, integration, and ERT steps of viral replication. Tetrameric SAMHD1 (orange), which can reside in the cytosol (beige) and nucleus (dark grey), restricts the HIV-1 lifecycle at three points during viral infection of a macrophage. The SAMHD1-mediated low dNTP pools in macrophages inhibit reverse transcription in the cytosol (red inhibition arrow 1), gap repair within the nucleus (red inhibition arrow 2), and ERT activity occurring extracellularly (red inhibition arrow 3).