Table 2.
Major metabolic pathways modulated during CrPV infection of S2 cells.
| Comparison | Pathway | Hits | Holm Adjusted P | FDR | Impact |
|---|---|---|---|---|---|
| 6 HPI vs. 0 HPI | None | ||||
| 12 HPI vs. 0 HPI | Galactose metabolism | 5 | 5.37 × 10−3 | 4.28 × 10−3 | 0.18 |
| Aminoacyl-tRNA biosynthesis | 7 | 8.45 × 10−3 | 4.28 × 10−3 | 0.00 | |
| Starch and sucrose metabolism | 4 | 1.39 × 10−2 | 4.77 × 10−3 | 0.21 | |
| 24 HPI vs. 0 HPI | None | ||||
| 36 HPI vs. 0 HPI | Arginine and proline metabolism | 7 | 8.43 × 10−4 | 8.43 × 10−4 | 0.33 |
| Aminoacyl-tRNA biosynthesis | 8 | 5.93 × 10−3 | 3.00 × 10−3 | 0.14 | |
| Alanine, aspartate and glutamate metabolism | 4 | 1.23 × 10−1 | 4.19 × 10−2 | 0.61 | |
| 12 HPI vs. 6 HPI | None | ||||
| 24 HPI vs. 12 HPI | Aminoacyl-tRNA biosynthesis | 9 | 1.05 × 10−4 | 1.05 × 10−4 | 0.14 |
| Galactose metabolism | 5 | 6.95 × 10−3 | 3.52 × 10−3 | 0.18 | |
| Starch and sucrose metabolism | 4 | 1.72 × 10−2 | 5.90 × 10−3 | 0.21 | |
| Arginine and proline metabolism | 5 | 3.90 × 10−2 | 1.01 × 10−2 | 0.29 | |
| Alanine, aspartate and glutamate metabolism | 4 | 5.78 × 10−2 | 1.22 × 10−3 | 0.61 | |
| 36 HPI vs. 24 HPI | Aminoacyl-tRNA biosynthesis | 8 | 1.95 × 10−3 | 1.95 × 10−3 | 0.14 |
| Arginine and proline metabolism | 5 | 5.12 × 10−2 | 2.59 × 10−2 | 0.33 |
Pairwise metabolite pathway analysis was conducted on the identified metabolite relative abundances between different time points after CrPV infection. Pathways with the most hits, highest Holm adjusted p-value (FDR < 0.05) and highest pathway impact values are considered the most significantly affected pathways. Hits refer to the number of metabolites that match to a particular metabolic pathway. The metabolic pathways with impact values > 0.1 are considered the most relevant pathways in the conditions under study.