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Sirtuin signaling pathway. Genes with overlapping actions observed in (A) Tat−/Meth vs. Tat−/Sal and in (B) Tat+/Meth vs. Tat−/Meth and assigned to sirtuin signaling were loaded into Cytoscape via Genemania; significant changes associated to assigned comparisons (p < 0.01) were visualized by loading the node attributes table. Tat−/Meth vs. Tat−/Sal p = 4.03 × 10−8 and Tat+/Meth vs. Tat−/Meth p = 3.24 × 10−7, with 50.4% and 46.4% overlap, respectively.
