Table 3.

Estimated marginal means of specific effects examined in people with primary generalized anxiety disorder (n = 87) in Study 2.

Outcome effect	Estimate [95% CI]	p	adj. pa	gc
Circulating PACAP [pM, log-transformed]
Genotype CC vs. other	0.07 [−0.04, 0.18]	0.20		0.27
Female	−0.07 [−0.17, 0.03]	0.16		−0.33
Genotype CC vs. other in men	0.07 [−0.10, 0.25]	0.42		0.30
Genotype CC vs. other in women	0.07 [−0.06, 0.19]	0.28		0.24
Genotype CC vs. other differenceb	0.00 [−0.21, 0.22]	0.98		n/a
PTSD lifetime diagnosis	−0.02 [−0.26, 0.23]	0.88		−0.13
Total anxiety symptom severity (HAM-A total scores)
Genotype CC vs. other	0.58 [−2.02, 3.18]	0.66	0.66	0.26
Female	−0.08 [−2.47, 2.30]	0.94	0.94	−0.11
Genotype CC vs. other in men	−0.95 [−5.29, 3.39]	0.66	0.66	−0.25
Genotype CC vs. other in women	2.11 [−0.77, 4.99]	0.15	0.22	0.53
Genotype CC vs. other differenceb	−3.06 [−8.26, 2.14]	0.25	0.37	n/a
PTSD lifetime diagnosis	1.21 [−4.45, 6.88]	0.67	0.80	0.18
Psychological anxiety symptom severity (HAM-A psychological scores)
Genotype CC vs. other	1.00 [−0.91, 2.90]	0.30	0.66	0.28
Female	−0.89 [−2.64, 0.86]	0.31	0.47	−0.31
Genotype CC vs. other in men	1.10 [−2.08, 4.27]	0.49	0.66	0.18
Genotype CC vs. other in women	0.90 [−1.21, 3.00]	0.40	0.40	0.34
Genotype CC vs. other differenceb	0.20 [−3.61, 4.01]	0.92	0.92	n/a
PTSD lifetime diagnosis	0.89 [−3.26, 5.04]	0.67	0.80	0.08
Somatic anxiety symptom severity (HAM-A somatic scores)
Genotype CC vs. other	−0.41 [−1.66, 0.84]	0.51	0.66	0.12
Female	0.80 [−0.35, 1.94]	0.17	0.47	0.25
Genotype CC vs. other in men	−2.05 [−4.12, 0.03]	0.05	0.16	−1.00
Genotype CC vs. other in women	1.22 [−0.16, 2.60]	0.08	0.22	0.62
Genotype CC vs. other differenceb	−3.27 [−5.76, −0.77]	0.01	0.03	n/a
PTSD lifetime diagnosis	0.35 [−2.37, 3.07]	0.80	0.80	0.26
Sleep quality (PSQI global scores)
Genotype CC vs. other	0.73 [−0.62, 2.08]	0.28		0.66
Female	−0.29 [−1.45, 0.87]	0.62		−0.15
Genotype CC vs. other in men	0.35 [−2.08, 2.79]	0.77		0.07
Genotype CC vs. other in women	1.11 [−0.05, 2.27]	0.06		0.81
Genotype CC vs. other differenceb	−0.75 [−3.45, 1.94]	0.58		n/a
PTSD lifetime diagnosis	3.24 [0.99, 5.49]	0.01		1.07

Genotypes are PAC1R SNP (rs2267735) genotypes, and effects shown are based on specific contrasts between estimated marginal means estimated within a single generalized linear model for each outcome

^aadj. p = adjusted for false discovery rate among HAM-A total and subscales only

^bDifference refers here to the sex difference in the CC vs. other (CG and GG) genotype effect (i.e., the interaction of gender and genotype effects)

^cHedges’ g effect size of group differences based on raw means