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. 2020 Apr 20;12(4):378. doi: 10.3390/pharmaceutics12040378

Table 1.

Composition of Cyclosporine A- and Tacrolimus-based galenic formulations.

Formulation Composition/Quantity Description/Function
Cyclosporine A (1%)
Cyclosporine A ethanol free formulation (CSA)

  • Cyclosporine A

 100 mg Active substance

  • Polyethoxylated castor oil - Cremophor RH 40

 1000 mg Emulsifier

  • Polyvinylpyrrolidone (PVP)

 200 mg Polymer/Co-Emulsifier

  • Ultrapure water

 to reach final volume
Cyclosporine A —classical galenic (SAND)

  • Sandimmun® solution

 50 mg/mL Active substance—
injectable solution

  • Cyclosporine A

 100 mg

  • Ethanol

 556 mg Solvent

  • Polyethoxylated castor oil - Cremophor

 1444 mg Emulsifier

  • Lacrimart®

 8 mL: Artificial tear

  • Benzalkonium chloride

 Preservative

  • Methyl cellulose

 Thickener

  • NaCl e KCl

 Osmotic agent

  • Edetic acid

 Chelating agent

  • Ultrapure water

 to reach final volume
Tacrolimus (0.1%)
Tacrolimus ethanol free formulation (TAC)

  • Tacrolimus

 10 mg Active substance

  • Polyethoxylated castor oil—Cremophor RH 40

 1000 mg Emulsifier

  • Polyvinylpyrrolidone (PVP)

 200 mg Polymer/Co-Emulsifier

  • Ultrapure water

 to reach final volume
Tacrolimus—
classical galenic (PROG)

  • Prograf® solution

 5 mg/mL Active substance—
injectable solution

  • Tacrolimus

 10 mg

  • Ethanol

 1620 mg Solvent

  • Olyethoxylated castor oil—Cremophor

 380 mg Emulsifier

  • Lacrimart®

 8 mL: Artificial tear

  • Benzalkonium chloride

 Preservative

  • Methyl cellulose

 Thickener

  • NaCl e KCl

 Osmotic agent

  • Edetic acid

 Chelating agent

  • Ultrapure water

 to reach final volume