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. 2020 May 11:ciaa558. doi: 10.1093/cid/ciaa558

Hydroxychloroquine in COVID-19 patients: what still needs to be known about the kinetics

G Martin-Blondel 1,1, S Ruiz 2,1, M Murris 3, S Faguer 4, V Duhalde 5, F Eyvrard 5, J Izopet 6, J M Mansuy 6, Y Rolland 7, K Delavigne 8, R Guimbaud 9, G Pugnet 10, J M Conil 2, B Georges 2, P Delobel 1, V Minville 2, S Silva Sifontes 11, D Concordet 12, P Gandia 12,13,✉
PMCID: PMC7239205  PMID: 32392332

Abstract

Different dosage regimens of hydroxychloroquine are used to manage COVID-19 patients, without information on the pharmacokinetics in this population.Blood samples (n=101) were collected from 57 COVID-19 patients for 7 days and concentrations were compared with simulated kinetic profiles.Hydroxychloroquine exposure is low and cannot be predicted by other populations.

Keywords: COVID-19, hydroxychloroquine, drug monitoring, population pharmacokinetic modelling, dosage regimens

Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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