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Age distributions for cases with PAH from the National Biological Sample and Data Repository for Pulmonary Arterial Hypertension (N = 2,572). BMPR2, TBX4, and SOX17 variant carriers have younger mean age of onset than the whole cohort with significant enrichment of pediatric-onset cases among TBX4 variant carriers compared with the whole cohort. Dotted vertical lines indicate the group means. See Figure 1 legend for expansion of abbreviation.
