Are disease-related pulmonary perfusion abnormalities detectable in COVID-19 patients? Suspicious findings in a lung perfusion SPECT performed for ruling out classical pulmonary embolism

PET/CT identifies FDG uptake, but presently there is no role for Nuclear Medicine in COVID-19 [1, 2]. However, thrombophilia is reported, and pulmonary emboli described [3–5]. In an 85-year-old man with dilated cardiomyopathy referred to the hospital because of dyspnea and cough, CT revealed bilateral pleural effusion with lower lobe ground glass opacities, but nasopharyngeal swab was negative for COVID-19, and hemoptysis plus persistence of severe hypoxemia with hypocapnia raised the suspicion of pulmonary embolism. Owing to elevated creatinine level, pulmonary perfusion SPECT was preferred, and initially reported as abnormal, but not diagnostic of acute embolism, because of uptake defects mainly coinciding with parenchymal anomalies. Subsequently, a second swab revealed infection by SARS-CoV-2. The patient was transferred to a COVID Unit, developed respiratory failure and fever (38.5°), and died 3 days later; last D-dimer was 1299 ng/mL and LDH 350 U/L. The lung scan was then reviewed after fusion with last CT. Figures 1 and 2 show the presence in the perfusion SPECT images (left panel, upper row: transaxial and coronal slices; lower row: sagittal slice and three-dimensional rendering) of small peripheral uptake defects (white arrows and arrowhead). In the corresponding CT images (right panel: same disposition, scout image in the lower right corner), the red arrows point to the parenchymal areas corresponding to the perfusion defects, which appear normally ventilated. These findings suggest that lung perfusion SPECT could identify perfusion abnormalities in early phase of COVID-19. Further studies are desirable to establish whether this could be helpful for these patients.

Fig. 1.

Left panel: perfusion SPECT images, transaxial and coronal slices in the upper row, sagittal slice and three-dimensional rendering in the lower row. Small peripheral uptake defects are present (white arrows and arrowhead). Right panel: CT images, same slice disposition, plus scout image (lower right corner). The red arrows point to the parenchymal areas corresponding to the perfusion defects

Fig. 2.

Same image disposition as in Fig. 1, showing similar findings in more basal fields

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