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(A) smFRET construct design to investigate G4 resolvase activity of the CST complexes. (B) smFRET data depicting the efficient unfolding of the G4 construct by CST, less efficient unfolding in presence of CS, and no unfolding with ST. (C) Time-resolved unfolding and identification of intermediates in presence of CST. (D) Model for the interplay between the CST complex and Polα. This Figure is adapted from Feng et al. [23] and used under Creative Commons Non-Commercial License (CC-BY).
