Table 2.

Pharmaceutical drugs targeting the ACE2 pathway.

Category of Action	Mechanism of Action	Examples of Drugs/Active Ingredient	References
1. ACE2 activators	Decrease expression of ACE	Felodipine combined with puerarin *	Bai, et al. [68]
		Ibuprofen #	Qiao, et al. [69]
	Decrease expression of AT1R	Felodipine combined with puerarin *	Bai, Huang, Chen, Wang and Ding [68]
		Ibuprofen #	Qiao, Wang, Chen, Zhang, Liu, Lu, Guo, Yan, Sun and Hu [69]
	Decrease expression of serum Ang II	Felodipine combined with puerarin *	Bai, Huang, Chen, Wang and Ding [68]
		Ibuprofen #	Qiao, Wang, Chen, Zhang, Liu, Lu, Guo, Yan, Sun and Hu [69]
	Increase expression of ACE 2	Candesartan CILEXETIL #	Arumugam, et al. [70]
		Felodipine combined with puerarin *	Bai, Huang, Chen, Wang and Ding [68]
		Ibuprofen #	Qiao, Wang, Chen, Zhang, Liu, Lu, Guo, Yan, Sun and Hu [69]
		Propofol *	Cao, et al. [71]
		Telmisartan #	Sukumaran, et al. [72]
		Xanthenone and resorcinolnaphthalein *	Hernández Prada, et al. [73]
	Increase expression of Ang-(1-7)	Candesartan CILEXETIL #	Arumugam, Thandavarayan, Palaniyandi, Giridharan, Arozal, Sari, Soetikno, Harima, Suzuki and Kodama [70]
		Felodipine combined with puerarin *	Bai, Huang, Chen, Wang and Ding [68]
		Ibuprofen #	Qiao, Wang, Chen, Zhang, Liu, Lu, Guo, Yan, Sun and Hu [69]
		TBTIF (4-tert-butyl-2,6-bis(thiomorpholin-4-ylmethyl)phenol) #	Flores-Monroy, et al. [74]
	Increase expression of Mas receptor	Candesartan CILEXETIL #	Arumugam, Thandavarayan, Palaniyandi, Giridharan, Arozal, Sari, Soetikno, Harima, Suzuki and Kodama [70]
		Felodipine combined with puerarin *	Bai, Huang, Chen, Wang and Ding [68]
		Ibuprofen #	Qiao, Wang, Chen, Zhang, Liu, Lu, Guo, Yan, Sun and Hu [69]
		Telmisartan #	Sukumaran, Veeraveedu, Gurusamy, Lakshmanan, Yamaguchi, Ma, Suzuki, Kodama and Watanabe [72]
2. Ang-(1-7) Mas receptor agonist	Increase activation of Mas receptor	AVE 0991 #	Santos, Ferreira and e Silva [22]

* Hypertension; # Cardiovascular disease.