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The periplasmic multidrug binding sites of MtrDCR103. (A) The periplasmic cleft entrance. Residues that may be important for selectivity are shown as dark yellow sticks. (B) The proximal drug binding site. The MtrDCR103 residues that are conserved with those for AcrB are in orange sticks. (C) The distal drug binding site. The MtrDCR103 residues that are conserved with those for AcrB are in light yellow sticks. The F loop and G loop are colored green and red, respectively, in A, B, and C.
