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ISL1 (A) and HOXA11 immunostaining (B) in an intact 13-week human fetal reproductive tract (AC122) grown for 4 weeks in a DES-treated ovariectomized female athymic mouse host. ISL1-reactive mesenchyme (A) surrounds vaginal squamous/transitional epithelium. The adenotic epithelium is unreactive. The mesenchyme of the endometrial stroma is highly and diffusely HOXA11 reactive (B).
