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. 2020 Apr 27;10(13):5829–5844. doi: 10.7150/thno.44051

Figure 9.

Figure 9

Oral administration of trehalose prevents cisplatin-induced AKI. (A) Mice intraperitoneally injected with cisplatin were orally administered trehalose at the same time for 2 days. (B) Serum BUN and Crea levels were quantified in each group (n = 8 - 10 mice). (C) Representative images of HE- and PAS-stained kidney sections. (D - F) The expression levels of apoptosis-related proteins (Bax and Bcl-2), autophagy-related proteins (TFEB and LC3), and mitochondria-related proteins (Drp1, Opa1, ATP5a, Sirt3 and Ndufs4) were measured by western blotting (n = 3 mice). Data analyzed by one-way ANOVA with Tukey's test. * P < 0.05, ** P < 0.01 vs. Con; & P < 0.05, && P < 0.01 vs. Cisp. (NC, normal control; Cisp, cisplatin; Tre, trehalose; C + T, cisplatin + trehalose; i.g., intragastric; BUN, blood urea nitrogen; Crea, serum creatinine; HE, hematoxylin/eosin; PAS, periodic acid-Schiff).