In a recent article, Ma et al. suggested that patients with cancer will be more susceptible to severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection and complications, although data on COVID-19 and malignancies remain limited.1 In a small study, Liang et al. noted that patients with cancer were more likely to experience severe sequelae of SARS-CoV-2 infection, such as intensive care admission, invasive ventilation or death.2 However, Wang and Zhang argued that the most important morbidity factor is exposure to an infection source, whereas worse outcomes from SARS-CoV-2 infection could be associated (at least partly) with older age of patients with cancer.3 Xia and colleagues also concluded that current evidence is insufficient to confirm an association between cancer and COVID-19.4 These issues have important implications for management of patients with malignancies during pandemics of COVID-19 that continues to evolve in many countries including Russia.
In a nationwide study, we evaluated the prevalence of malignancies among 1307 intensive care unit (ICU) patients with SARS-CoV-2 pneumonia who required respiratory support. Medical records were submitted via Internet by the COVID-19 hospitals located in 60 regions across Russia to the Federal Center at the Sechenov University (Moscow) that provided advice on management of patients. Diagnosis of SARS-CoV-2 pneumonia was confirmed both by polymerase chain reaction (PCR) and CT. In patients with inconclusive or pending results of PCR, SARS-CoV-2 pneumonia was defined as severe acute respiratory infection with typical CT findings (bilateral multilobar ground-glass opacification with a peripheral or posterior distribution, or multifocal consolidative opacities superimposed on ground-glass opacification)5 and no other obvious aetiology.
Various tumors were reported by the local physicians in 31 patients (2.4%). However, only 19 patients (1.5%) had active tumors or underwent chemotherapy or surgery in the past 3 months (Table 1 ). As expected, lung and breast cancers were the most common malignancies. Median age of patients was 66 years. Most patients were older than 60 and/or had comorbidities, such as cardiovascular diseases and type 2 diabetes.
Table 1.
Characteristic of patients with COVID-19 and malignancies
| Location of tumor | Age/ gender | Status/treatment | Comorbidites |
|---|---|---|---|
| Cervix | 55/F | Surgery | - |
| Parotid gland | 68/M | Relapse (2019) | History of tuberculosis |
| Lung | 58/M | Chemotherapy (2020) | - |
| Pancreas | 63/F | Untreated | Hepatitis C |
| Breast | 68/F | Mastectomy (2019) | Hypertension, diabetes, obesity |
| Breast | 89/F | Mastectomy (2017) | Diabetes, history of MI |
| Colon | 75/M | Colectomy (2019) | History of MI, asthma |
| Brain | 58/M | Surgery (2020) | Obesity |
| Liver | 67/M | Untreated | Diabetes, coronary stenting, hepatitis B |
| Stomach | 75/M | Gastrectomy (2020) | Hypertension |
| Kidney | 72/F | Surgery (2019) | Peritonitis (2020) |
| Prostate | 61/M | Untreated | Hypertension, obesity |
| Breast | 88/F | Mastectomy and chemotherapy (2015) | - |
| Thyroid gland | 57/F | Untreated | Hypertension, diabetes, tuberous sclerosis |
| Rectum | 56/F | Surgery (2020) | Hypertension |
| Breast | 75/F | Mastectomy (2019) | |
| Breast | 83/F | Mastectomy (2019) | Hypertension |
| Breat | 75/F | Mastectomy | Hypertension, diabetes |
| Lung | 80/F | Chemotherapy (2020) | Hypertension |
| Ewing sarcoma | 70/M | No data | COPD |
| Lung | 78/F | Surgery (2020) | Hypertension |
| Stomach | 60/F | Gastrectomy (2020) | Hypertension, diabetes |
| Breast | 79/F | Mastectomy and chemotherapy (2020) | - |
| Liver | 64/M | Untreated | Hypertension, history of stroke |
| Colon | 69/M | Untreated | Hypertension, diabetes |
| Lung | 83/M | Untreated | Hypertension, history of MI |
| Liver | 66/M | Untreated | Hypertension |
| Duodenum | 73/M | Surgery and chemotherapy (2019) | Hypertension, history of MI |
| Kidney | 46/M | Surgery (2016) | Hypertension |
| Kidney | 63/M | Untreated | Hypertension, dialysis, history of stroke |
| Histiocytoma | 55/M | Surgery and chemotherapy (2020) | Pulmonary embolism |
Note: MI – myocardial infarction
In summary, the prevalence of malignancies was low among ICU patients with SARS-CoV-2 infection and did not exceed that in the general population. Therefore, patients with malignant tumors were not overrepresented in this cohort of patients with severe infection. We realize that our reassuring findings may be misleading, since we do not know the total number of cancer patients who contracted SARS-CoV-2 in Russia and cannot definitely conclude that malignancy did not worsen outcomes of COVID-19. However, our data suggest that other factors, such as older age and comorbidities, contribute significantly to the more severe course of SARS-CoV-2 infection in cancer patients.
Acknowledgments
We declare no competing interests.
References
- 1.Ma J., Yin J., Qian Y., Wu Y. Clinical characteristics and prognosis in cancer patients with COVID-19: A single center's retrospective study. J Infect. 2020;S0163-4453(20):30214. doi: 10.1016/j.jinf.2020.04.006. [published online ahead of print, 2020 Apr 14] -0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Liang W., Guan W., Chen R. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335–337. doi: 10.1016/S1470-2045(20)30096-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Wang H., Zhang L. Risk of COVID-19 for patients with cancer. Lancet Oncol. 2020;21(4):e181. doi: 10.1016/S1470-2045(20)30149-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Xia Y., Jin R., Zhao J. Risk of COVID-19 for patients with cancer. Lancet Oncol. 2020;21(4):e180. doi: 10.1016/S1470-2045(20)30150-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Salehi S., Abedi A., Balakrishnan S., Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 Patients. AJR Am J Roentgenol. 2020 Mar 14:1–7. doi: 10.2214/AJR.20.23034. [Epub ahead of print] [DOI] [PubMed] [Google Scholar]