The Suppressive Effect of Supplementation of Combined Probiotic on Helicobacter pylori Infection

Abstract

Objectives

Helicobacter pylori (H. pylori) is the leading cause of chronic gastritis and gastric ulcers and significantly increases the risk of developing gastric cancer. Even though many therapeutic improvements in H. pylori eradication rate, it is still associated with the high prevalence of infection. Several studies have verified that probiotics treatment were beneficial to gastrointestinal tract infections is increasingly documented as an alternative to antibiotics. This study aimed to investigate the efficacy of novelty probiotic complex on H. pylori infection in patients.

Methods

Between October 2018 and August 2019, all subjects with a clinical of Chung Shan Medical University Hospital in Taiwan, subjects who confirmed H. pylori infection (n = 20) were randomized to receive probiotic complex or placebo for 3 weeks. The probiotic complex contained Lactobacillus johnsonii No.1088 (HK-LJ88) 10¹⁰ CFU/mL, Bacillus subtilis 10¹² CFU/mL, green tea extract and sake lees. Primary outcome of this study was The amounts of change of ¹³C urea breath test (¹³C UBT) that was assessed 3 weeks after the end of supplementation. The hematological results, dietary records, anthropogenic indicators were measured/assessed at the 0 and 3^th week.

Results

Subjects in the probiotic group had significantly lower ¹³C UBT (39.6%) at the 3^th week when compared to the value at week 0. In contrast with subjects in the placebo group had higher 50% ¹³C UBT. The levels of anthropometric indices, blood glucose and lipid profiles had no significant changes during the intervention study period in both groups. After adjusting for age and gender, supplement had significant effect on reducing the change of ¹³C UBT (β = -13.64, p = 0.047) and diastolic blood pressure (β = -6.91, p = 0.03).

Conclusions

These results suggest that supplement with the combination of probiotic Lactobacillus johnsonii and Bacillus subtilis for 3 weeks may have a favorable effect on H. pylori infection in humans. The probiotics intervention also resulted in improved blood pressure.

Funding Sources

Yang Ming Biomed Co., Ltd.