Table 1.
List of compounds tested and their IC50 values in FluPol in vitro RNA synthesis assays.
| COMPOUND | CHEMICAL NAME | SOURCE | FLUPOL IC50 | FOLD CHANGE IC50* |
|---|---|---|---|---|
| FAV00A | N-methyl-4-benzylcarbamidopyridinium iodide | Farmak JSC | 46.3 mM | 1 |
| FAV00B | N-methyl-4-benzylcarbamidopyridinium chloride | Farmak JSC | - | - |
| VR16-01 | 4-{[(2-hydroxyphenyl)methyl]carbamoyl}-1-methylpyridin-1-ium | Farmak JSC | 78.2 mM | 0.6 |
| VR17-01 | 4-{[(3-hydroxyphenyl)methyl]carbamoyl}-1-methylpyridin-1-ium | Farmak JSC | Ns | - |
| VR17-02 | 4-{[(4-hydroxyphenyl)methyl]carbamoyl}-1-methylpyridin-1-ium | Farmak JSC | Ns | - |
| VR17-03 | N-benzyl-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide | Farmak JSC | Ns | - |
| VR17-04 | 4-(benzylcarbamoyl)-3-hydroxy-1-methylpyridin-1-ium | Farmak JSC | 0.84 mM | 55 |
| VR18-01 | N-[(2-hydrophenyl)methyl]pyridine-4-carboxamide | Farmak JSC | 34.2 mM | 1.4 |
| VR18-02 | N-[(3-hydrophenyl)methyl]pyridine-4-carboxamide | Farmak JSC | 94.8 mM | 0.5 |
| VR18-03 | N-[(4-hydrophenyl)methyl]pyridine-4-carboxamide | Farmak JSC | 74.01 mM | 0.6 |
| VR18-04 | N-benzyl-2-oxo-1,2-dihydropyridine-4-carboxamide | Farmak JSC | 35.16 mM | 1.3 |
| T-705 TRIPHOSPHATE | 6-fluoro-3,4-dihydro-4-[5-O-(hydroxy{[hydroxy(phosphonooxy)phosphinyl]oxy}phosphinyl)-β-d-ribofuranosyl]-3-oxo-2-pyrazinecarboxamide | ChemCruz | 0.011mM | 420 |
| REMDESIVIR TRIPHOSPHATE | Sodium ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][l,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate | MedChem Express | - | - |
*
Fold change relative to FAV00A.
Ns = non-soluble. - = not tested.