Figure 2.

Single subcutaneous injection of capsaicin attenuates mechanical hyperalgesia in mice with ION-CCI. A, B, Mechanical sensitivity in the ipsilateral V2 skin (A) or in the ipsilateral V3 skin (B). Vehicle or capsaicin (10 µg) was subcutaneously injected into the ipsilateral V2 skin area 14 d after CCI or sham surgery. C, D, Percent response frequency in response to VF hair 3.61 (C) or 4.08 (D). Symbols and n numbers within parenthesis in A, B are also applied to C, D. Two-way ANOVA followed by Bonferroni post hoc test (CCI/Veh vs CCI/Cap); *p < 0.05, **p < 0.01, ****p < 0.0001.