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. 2020 May 5;39(23):4538–4550. doi: 10.1038/s41388-020-1307-3

Fig. 1. miR-1258 suppresses HCC cell metastasis in vitro and in vivo and its expression associated with E-HCC recurrence and patient’s survival.

Fig. 1

a The expression of miR-1258 in 20 paired E-HCC tissues and adjacent normal tissues. b Correlation of recurrence-free survival (RFS) and overall survival (OS) and miR-1258 expression by Kaplan–Meier analysis in TCGA datasets. c Correlation of RFS and OS and miR-1258 expression by Kaplan–Meier analysis in SYSUCC datasets. d The expression of miR-1258 in immortalized liver cells (THLE-3) and four HCC cell lines (SMMC-7721, Huh-7, HepG2, and Hep3B). e The wound-healing assay of HCC cells. f The invasion assay of HCC cells. g The numbers of lung metastasis. Experiments performed in triplications. miR-1258, HCC cells were transfected by miR-1258 expression vector. Anti-miR-1258, HCC cells were transfected by miR-1258 antisense plasmid. *P < 0.05.