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. 2014 Jul 7;32:57–96. doi: 10.1016/B978-0-12-039232-2.50007-4

Feline Leukemia/Sarcoma Viruses and Immunodeficiency

JENNIFER ROJKO *, MYRON ESSEX †, ZE'EV TRAININ ‡
PMCID: PMC7271325  PMID: 2847504

Publisher Summary

This chapter discusses the structure feline leukemia virus (FeLV) and pathogenesis of lymphomas and leukemias BY FeLV. FeLV is quite similar to the better-studied murine leukemia viruses in structure and genetic map. The virus particles bud from cytoplasmic membranes into either extracellular spaces or into vacuoles. FeLV has long been considered a typical noncytopathogenic, longlatency leukemia virus based on its behavior in fibroblasts in vitro. Recent evidence suggests that its in vivo behavior in critical target hemolymphatic tissues is as likely to be cytopathic as transforming. The type of FeLV-related disease that occurs and the disease-free interval probably are influenced by viral envelope proteins and glycoproteins and the consequences of proviral integration. FeLV subgroup specificity apparently determines when and what type of disease will occur. The ecotropic FeLV-A is the most frequent subgroup found in pet cats and is transmitted contagiously. Immunosuppression is the most frequent and the most devastating manifestation of FeLV viremia in clinical and experimental studies. It seems that multiple cell types and multiple processes are involved in the development of feline retrovirus-induced immunosuppression. Although no solid evidence is available for the malfunctioning of cat T helper cells because of the paucity of T-cell specific markers, the circumstantial evidence provided thus far indicates an impaired T helper function in FeLV-infected cats similar to that observed in humans infected with HIV. Studies on the pathogenesis of FeLV-induced immunosuppression might provide a valuable mode for a better understanding and means of control of human AIDS.

References

  1. Abkowitz J.L., Ott R.L., Nakamura J.M., Steinmann L., Fialkow P.J., Adamson J.W. J. Clin. Invest. 1985;75:133–140. doi: 10.1172/JCI111665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Abkowitz J.L., Holly R.D., Segal G.M., Adamson J.W. J. Cell. Physiol. 1986;127:189–196. doi: 10.1002/jcp.1041270123. [DOI] [PubMed] [Google Scholar]
  3. Anderson L.J., Jarrett W.F.H. Res. Vet. Sci. 1971;12:179–180. [PubMed] [Google Scholar]
  4. Anderson L.J., Jarrett W.F.H., Jarrett O., Laird H.M. J. Natl. Cancer Inst. 1971;47:807–817. [PubMed] [Google Scholar]
  5. Azocar J., Essex M. Cancer Res. 1979;39:3388–3391. [PubMed] [Google Scholar]
  6. Beckenhauer W.H., Sharpee R.L., Baumgartener L., Davis E., Thurber E.T. Norden News, Top. Vet. Med. 1984;1:1–15. [Google Scholar]
  7. Besmer P. Contemp. Top. Microbiol. Immunol. 1983;107:1–27. doi: 10.1007/978-3-642-69075-4_1. [DOI] [PubMed] [Google Scholar]
  8. Besmer P., Hardy W.D., Jr., Zuckerman E.E., Bergold P., Lederman L., Snyder H.W., Jr. Nature (London) 1983;303:825–828. doi: 10.1038/303825a0. [DOI] [PubMed] [Google Scholar]
  9. Besmer P., Murphey J.E., George P.C., Qiu F.H., Bergold P.J., Lederman L., Snyder H.W., Jr., Brodeur D., Zuckerman E.E., Hardy W.D., Jr. Nature (London) 1986;320:415–421. doi: 10.1038/320415a0. [DOI] [PubMed] [Google Scholar]
  10. Boyce J.T., Hoover E.A., Kociba G.J., Olsen R.G. Exp. Hematol. 1981;9:990–1001. [PubMed] [Google Scholar]
  11. Boyce J.T., Kociba G.J., Jacobs R.M., Weiser R.G. Vet. Pathol. 1986;23:16–20. doi: 10.1177/030098588602300103. [DOI] [PubMed] [Google Scholar]
  12. Braun M.J., Deininger P.L., Casey J.W. J. Virol. 1985;55:177–183. doi: 10.1128/jvi.55.1.177-183.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Busch M.P., Devi B.G., Soe L.H., Perbal B., Baluda M.A., Roy-Burman P. Hematol. Oncol. 1983;1:61–75. doi: 10.1002/hon.2900010108. [DOI] [PubMed] [Google Scholar]
  14. Casey J.W., Roach A., Mullins J.I., Burck K.B.J., Nicolson M.O., Gardner M.B., Davidson N. Proc. Natl. Acad. Sci. U.S.A. 1981;78:7778–7782. doi: 10.1073/pnas.78.12.7778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Chen A.P., Essex M.E. Cancer Invest. 1984;2:81–90. doi: 10.3109/07357908409020290. [DOI] [PubMed] [Google Scholar]
  16. Cianciolo G.J., Copeland T.D., Oroszlan S., Snyderman R. Science. 1985;230:453–455. doi: 10.1126/science.2996136. [DOI] [PubMed] [Google Scholar]
  17. Cockerell G.L., Hoover E.A. Cancer Res. 1977;37:3985–3989. [PubMed] [Google Scholar]
  18. Coffin J.M., Varmus H.E., Bishop J.M., Essex M., Hardy W.D., Martin G.S., Rosenberg N.E., Scolnick E.M., Weinberg R.A., Vogt P.K. J. Virol. 1981;40:953–957. doi: 10.1128/jvi.40.3.953-957.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Cotter S.M., Hardy W.D., Jr., Essex M.E. J. Am. Vet. Med. Assoc. 1975;166:449–454. [PubMed] [Google Scholar]
  20. Day N.K., O'Reilly-Felice C., Hardy W.D., Jr., Good R.A., Witkin S.S. J. Immunol. 1980;126:2363–2366. [PubMed] [Google Scholar]
  21. de Noronha F., Schafer W., Essex M., Bolognesi D.P. Virology. 1978;85:617–621. doi: 10.1016/0042-6822(78)90467-1. [DOI] [PubMed] [Google Scholar]
  22. Dubey J.P., Stauton D., Azocar J., Stux S., Essex M., Yunis E.J. Clin. Immunol. Immunopathol. 1982;23:215–223. doi: 10.1016/0090-1229(82)90109-x. [DOI] [PubMed] [Google Scholar]
  23. Dunlap J.E., Nichcols W.S., Hebebrand L.C., Mather L.E., Olsen R.G. Cancer Res. 1979;39:956–959. [PubMed] [Google Scholar]
  24. Elder J.M., Mullins J.I. J. Virol. 1983;46:871–890. doi: 10.1128/jvi.46.3.871-880.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Engelman R.W., Tyler R.D., Good R.A., Day N.K. Cancer. 1985;56:777–781. doi: 10.1002/1097-0142(19850815)56:4<777::aid-cncr2820560413>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  26. Engelman R.W., Fulton R.W., Good R.A., Day N.K. Science. 1985;227:1368–1370. doi: 10.1126/science.2983424. [DOI] [PubMed] [Google Scholar]
  27. Engelman R.W., Machida K., Longley R.E., Liu W.T., Trang L.Q., Good R.A., Day N.K. In Vitro Cell Dev. Biol. 1986;22:273–279. doi: 10.1007/BF02621230. [DOI] [PubMed] [Google Scholar]
  28. Essex M. Adv. Cancer Res. 1975;21:175–248. doi: 10.1016/s0065-230x(08)60973-2. [DOI] [PubMed] [Google Scholar]
  29. Essex M., Snyder S.P. J. Natl. Cancer Inst. 1973;51:1007–1012. doi: 10.1093/jnci/51.3.1007. [DOI] [PubMed] [Google Scholar]
  30. Essex M., Klein G., Snyder S.P., Harrold J.B. Nature (London) 1971;233:195–197. doi: 10.1038/233195a0. [DOI] [PubMed] [Google Scholar]
  31. Essex M., Klein G., Snyder S.P., Harrold J.B. Int. J. Cancer. 1971;8:384–390. doi: 10.1002/ijc.2910080305. [DOI] [PubMed] [Google Scholar]
  32. Essex M., Hardy W.D., Jr., Cotter S.M., Jakowski R.M., Sliski A. Infect. Immun. 1975;11:470–475. doi: 10.1128/iai.11.3.470-475.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Essex M., Sliski A.H., Cotter S.M., Jakowski R.M., Hardy W.D., Jr. Science. 1975;190:790–792. doi: 10.1126/science.173019. [DOI] [PubMed] [Google Scholar]
  34. Essex M., Cotter S.M., Sliski A.H., Hardy W.D., Stephenson J.R., Aaronson S., Jarrett O. Int. J. Cancer. 1977;19:90–96. doi: 10.1002/ijc.2910190113. [DOI] [PubMed] [Google Scholar]
  35. Essex M., Sliski A.H., Hardy W.D., Cotter S.M., de Noronha F. Adv. Comp. Leuk. Res. 1978;8:337–340. [Google Scholar]
  36. Flower R.L.P., Wilox G.E., Cook R.D., Ellis T.M. Arch. Virol. 1985;83:53–63. doi: 10.1007/BF01310964. [DOI] [PubMed] [Google Scholar]
  37. Francis D.P., Essex M., Hardy W.D., Jr. Nature (London) 1977;269:252–254. doi: 10.1038/269252a0. [DOI] [PubMed] [Google Scholar]
  38. Francis D.P., Essex M., Gayzagian D. J. Clin. Microbiol. 1979;9:154–156. doi: 10.1128/jcm.9.1.154-156.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Fulton R., Forrest D., McFarlane R., Onions D., Neil J.C. Nature (London) 1987;326:190–194. doi: 10.1038/326190a0. [DOI] [PubMed] [Google Scholar]
  40. Glick A.D., Horn R.G., Holscher M. Am. J. Pathol. 1978;92:321–332. [PMC free article] [PubMed] [Google Scholar]
  41. Grant C.K., Michalek M.T. Int. J. Cancer. 1981;28:209–217. doi: 10.1002/ijc.2910280215. [DOI] [PubMed] [Google Scholar]
  42. Grant C.K., de Boer D.J., Essex M., Worley M.B., Higgins J. J. Immunol. 1977;119:401–406. [PubMed] [Google Scholar]
  43. Grant C.K., Essex M., Pedersen NC. J. Natl. Cancer Inst. 1978;60:161–166. doi: 10.1093/jnci/60.1.161. [DOI] [PubMed] [Google Scholar]
  44. Grant C.K., Harris D., Essex M.E., Pickard D.K., Hardy W.D., Jr., de Noronha F. J. Natl. Cancer Inst. 1980;64:1527–1533. doi: 10.1093/jnci/64.6.1527. [DOI] [PubMed] [Google Scholar]
  45. Grant C.K., Ernisse B.J., Jarrett O., Jones F.R. J. Immunol. 1983;131:3042–3048. [PubMed] [Google Scholar]
  46. Haley P.J., Hoover E.A., Quackenbush S.L., Gasper P.W., Macy D.W. J. Natl. Cancer Inst. 1985;74:889–892. [PubMed] [Google Scholar]
  47. Hamilton K.L., Rojko J.L., Rezanka L.J., Cheney C.M., Mathes L.E., Grant C.K., Nunberg J.H. Cancer Res. 1987 submitted. [Google Scholar]
  48. Hamilton K.L., Rojko J.L., Brown R.J., O'Brien S.J. Cancer Res. 1987 submitted. [Google Scholar]
  49. Hardy W.D., Jr. In: “Feline Leukemia Virus”. Hardy W.D., Essex M. Jr., McClelland A.J., editors. Elsevier; Amsterdam: 1980. pp. 3–31. [Google Scholar]
  50. Hardy W.D., Jr. Semin. Immunopathol. 1982:75–106. doi: 10.1007/BF00201958. [DOI] [PubMed] [Google Scholar]
  51. Hardy W.D., Jr. Cancer Invest. 1983;1:163–174. doi: 10.3109/07357908309042418. [DOI] [PubMed] [Google Scholar]
  52. Hardy W.D., Geering G., Old L.J., de Harven E., Brodey R.S., McDonough S. Science. 1969;166:1019–1021. doi: 10.1126/science.166.3908.1019. [DOI] [PubMed] [Google Scholar]
  53. Hardy W.D., Jr., Old L.J., Hess P.W., Essex M., Cotter S.M. Nature (London) 1973;244:266–269. doi: 10.1038/244266a0. [DOI] [PubMed] [Google Scholar]
  54. Hardy W.D., Jr., Hess P.W., MacEwen E.G., McClelland A.J., Zuckerman E.E., Essex M., Cotter S.M., Jarrett O. Cancer Res. 1976;36:582–588. [PubMed] [Google Scholar]
  55. Hardy W.D., McClelland A.J., Zukerman E.E., Hess P.W., Essex M., Cotter S.M., MacEwen E.G., Hayes A.A. Nature (London) 1976;263:326–328. doi: 10.1038/263326a0. [DOI] [PubMed] [Google Scholar]
  56. Hardy W.D., Jr., McClelland A.J., Zuckerman E.E., Snyder H.W., Jr., MacEwen E.G., Francis D., Essex M. Nature (London) 1980;288:90–92. doi: 10.1038/288090a0. [DOI] [PubMed] [Google Scholar]
  57. Hardy W.D., Jr., Zuckerman E.E., McClelland A.J., Snyder H.W., Essex M., Francis D. Cold Spring Harbor Conf. Cell Prolif. 1980;7:677–699. [Google Scholar]
  58. Hebebrand L.C., Olsen R.G., Mathes L.E., Nichols W.S. Cancer Res. 1979;39:443–447. [PubMed] [Google Scholar]
  59. Hawkins E.C., Johnson L., Pedersen N.C., Winston S. J. Am. Vet. Med. Assoc. 1986;188:1031–1034. [PubMed] [Google Scholar]
  60. Heding L.D., Schaller J.P., Blakeslee J.R., Olsen R.G. Cancer Res. 1976;36:1647–1652. [PubMed] [Google Scholar]
  61. Hoover E.A., McCullough C.B., Griesemer R.A. J. Natl. Cancer Inst. 1972;48:973–983. [PubMed] [Google Scholar]
  62. Hoover E.A., Perryman L.E., Kociba G.J. Cancer Res. 1973;33:145–152. [PubMed] [Google Scholar]
  63. Hoover E.A., Kociba G.J., Hardy W.D., Jr., Yohn D.S. J. Natl. Cancer Inst. 1974;53:1271–1276. doi: 10.1093/jnci/53.5.1271. [DOI] [PubMed] [Google Scholar]
  64. Hoover E.A., Olsen R.G., Hardy W.D., Jr., Schaller J.P., Mathes L.E. J. Natl. Cancer Inst. 1976;57:365–369. doi: 10.1093/jnci/57.2.365. [DOI] [PubMed] [Google Scholar]
  65. Hoover E.A., Olsen R.G., Mathes L.E., Schaller J.P. Cancer Res. 1977;37:3707–3710. [PubMed] [Google Scholar]
  66. Hoover E.A., Schaller J.P., Mathes L.E., Olsen R.G. Infect. Immun. 1977;16:54–59. doi: 10.1128/iai.16.1.54-59.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Hoover E.A., Krakowka S., Cockerell G.L., Mathes L.E., Olsen R.G. Am. J. Vet. Res. 1978;39:393–395. [PubMed] [Google Scholar]
  68. Hoover E.A., Rojko J.L., Wilson P.L., Olsen R.G. J. Natl. Cancer Inst. 1981;67:889–898. doi: 10.1093/jnci/67.4.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Hoover, E. A., Rojko, J. L., and Quackenbush, S. L. (1984). Int. Conf. RNA Tumor Viruses Hum. Cancer, AMC Cancer Res. Center, Denver, June
  70. Jackowski S., Rettenmier C.W., Sherr C.J., Rock C.O. J. Biol. Chem. 1986;261:4978–4985. [PubMed] [Google Scholar]
  71. Jacobs R.M., Boyce J.T., Kociba G.J. Cytometry. 1986;7:64–69. doi: 10.1002/cyto.990070109. [DOI] [PubMed] [Google Scholar]
  72. Jacquemin P.C., Sexinger C., Gallo R.C., Hardy W.D., Essex M. Virology. 1978;91:472–476. doi: 10.1016/0042-6822(78)90393-8. [DOI] [PubMed] [Google Scholar]
  73. Jähner P., Jaenisch R. Mol. Cell Biol. 1985;5:2212–2220. doi: 10.1128/mcb.5.9.2212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Jakowski R.M., Essex M., Hardy W.D., Jr., Stephenson J.R., Cotter S.M. In: “Feline Leukemia Virus”. Hardy W.D., Essex M., McClelland A.J., editors. Elsevier; New York: 1980. p. 141. [Google Scholar]
  75. Jameson P., Essex M. Antiviral Res. 1983;3:115–120. doi: 10.1016/0166-3542(83)90033-5. [DOI] [PubMed] [Google Scholar]
  76. Jarrett O., Russell P.H. Int. J. Cancer. 1978;21:466–472. doi: 10.1002/ijc.2910210411. [DOI] [PubMed] [Google Scholar]
  77. Jarrett O., Russell P.H., Stewart M.F. Vet. Rec. 1977;101:304–305. doi: 10.1136/vr.101.15.304. [DOI] [PubMed] [Google Scholar]
  78. Jarrett O., Hardy W.D., Golder M.C., Jr., Hay D. Int. J. Cancer. 1978;21:334–337. doi: 10.1002/ijc.2910210314. [DOI] [PubMed] [Google Scholar]
  79. Jarrett O., Golder M.C., Toth S., Onions D.E., Stewart M.F. Int. J. Cancer. 1984;34:1283–1288. doi: 10.1002/ijc.2910340222. [DOI] [PubMed] [Google Scholar]
  80. Jarrett W.F.H., Crawford E.M., Martin W.B., Davie F. Nature (London) 1964;202:567–569. doi: 10.1038/202567a0. [DOI] [PubMed] [Google Scholar]
  81. Jarrett W.F.H., Jarrett O., Mackey L., Laird H., Hardy W.D., Jr., Essex M. J. Natl. Cancer Inst. 1973;51:833–841. doi: 10.1093/jnci/51.3.833. [DOI] [PubMed] [Google Scholar]
  82. Jarrett W., Mackey L., Jarrett O., Laird H., Hood C. Nature (London) 1974;243:230–232. doi: 10.1038/248230a0. [DOI] [PubMed] [Google Scholar]
  83. Jarrett W., Jarrett O., Mackey L., Laird H., Hood C., Hay D. Int. J. Cancer. 1975;16:134–141. doi: 10.1002/ijc.2910160115. [DOI] [PubMed] [Google Scholar]
  84. Jarrett, W. F. H., Jarrett, J. O., and Mackey, L. J. (1976). United States Patent No. 3,966,907, June 29.
  85. Johnson L., Pedersen N.C., Theilen G.H. Vet. Immunol. Immunopathol. 1985;9:283–300. doi: 10.1016/0165-2427(85)90078-9. [DOI] [PubMed] [Google Scholar]
  86. Jones R.F., Grant C.K., Snyder H.W., Jr. Biol. Response Mod. 1984;3:286–292. [PubMed] [Google Scholar]
  87. Klotz F.W., Cooper M.D. J. Immunol. 1986;136:2510–2514. [PubMed] [Google Scholar]
  88. Klotz F.J., Gathings W.E., Cooper M.D. J. Immunol. 1985;134:95–100. [PubMed] [Google Scholar]
  89. Kobilinsky L., Hardy W.D., Jr., Day N.K. J. Immunol. 1979;122:2139–2142. [PubMed] [Google Scholar]
  90. Kobilinsky L., Hardy W.D., Jr., Ellis R., Witkin S.S., Day N.K. Infect. Immun. 1980;29:165–170. doi: 10.1128/iai.29.1.165-170.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Kociba G.J., Hoover E.A., Sciulli V.M., Olsen R.G. Adv. Comp. Leuk. Res. 1982;10:211–212. [Google Scholar]
  92. Kociba G.J., Lange R.D., Dunn C.D., Hoover E.A. Vet. Pathol. 1983;20:548–552. doi: 10.1177/030098588302000506. [DOI] [PubMed] [Google Scholar]
  93. Kooistra L.H., Splitter G.A. Cell Immunol. 1985;94:466–479. doi: 10.1016/0008-8749(85)90271-0. [DOI] [PubMed] [Google Scholar]
  94. Kraut E.H., Rojko J.L., Olsen R.G., Tuomari D.L. J. Virol. 1985;54:873–875. doi: 10.1128/jvi.54.3.873-875.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Kraut E.H., Rojko J.L., Olsen R.G., Tuomari D.L. Am. J. Vet. Res. 1987;48:1063–1067. [PubMed] [Google Scholar]
  96. Lafrado L.J., Olsen R.G. Cancer Invest. 1986;4:297–300. doi: 10.3109/07357908609017509. [DOI] [PubMed] [Google Scholar]
  97. Lafrado L.J., Mathes L.E., Olsen R.G. Am. J. Vet. Res. 1986;47:820–821. [PubMed] [Google Scholar]
  98. Lane H.C., Masur H., Edgar L.C., Whalen G., Rook A.H., Fauci A.S. N. Engl. J. Med. 1983;309:453–458. doi: 10.1056/NEJM198308253090803. [DOI] [PubMed] [Google Scholar]
  99. Langweiler M., Cockerell G.L., de Noronha F. Cancer Res. 1983;43:1957–1960. [PubMed] [Google Scholar]
  100. Lee T.H., Essex M., de Noronha F., Azocar J. Cancer Res. 1982;42:3995–3999. [PubMed] [Google Scholar]
  101. Levy L.S., Gardner M.B., Casey J.W. Nature (London) 1984;308:853–856. doi: 10.1038/308853a0. [DOI] [PubMed] [Google Scholar]
  102. Lewis M.G., Mathes L.E., Olsen R.G. Infect. Immun. 1981;34:888–894. doi: 10.1128/iai.34.3.888-894.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  103. Liu W.T., Engelman R.W., Trang L.Q., Hau K., Good R.A., Day N.K. Proc. Natl. Acad. Sci. U.S.A. 1984;81:3516–3520. doi: 10.1073/pnas.81.11.3516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Liu, W. T., Good, R. A., Trang, L. Q., Engelman, R. W., Day, N. K. (1984b).
  105. Lewis M.G., Fertel R.H., Olsen R.G. Leuk. Res. 1985;9:1105–1109. doi: 10.1016/0145-2126(85)90099-2. [DOI] [PubMed] [Google Scholar]
  106. Lewis M.G., Fertel R.H., Olsen R.G. Leuk. Res. 1985;9:1451–1456. doi: 10.1016/0145-2126(85)90035-9. [DOI] [PubMed] [Google Scholar]
  107. Lewis M.G., Duska G.O., Stiff M.I., Lafrado L.J., Olsen R.G. J. Gen. Virol. 1986;67:2113–2118. doi: 10.1099/0022-1317-67-10-2113. [DOI] [PubMed] [Google Scholar]
  108. Lewis M.G., Chang H.Y., Olsen R.G., Fertel R.H. Biochem. Biophys. Res. Commun. 1986;141(3):1077–1083. doi: 10.1016/s0006-291x(86)80153-x. [DOI] [PubMed] [Google Scholar]
  109. Lubin J.R., Albert D.M., Essex M., de Noronha F., Riis R. Invest. Opthalmol. Vis. Sci. 1983;24:1055–1062. [PubMed] [Google Scholar]
  110. Luciw P., Parkes D., Potter S., Najerian R. In: “RNA Tumor Viruses, Supplement”. Weiss R., Teich N., Varmus H., Coffin J., editors. Cold Spring Harbor Laboratory; Cold Spring Harbor, New York: 1985. [Google Scholar]
  111. Luciw P., Parkes D., Van Nest G., Dina D., Hendrix K., Gardner M.B. Basic Life Sci. 1986;37:207–215. doi: 10.1007/978-1-4684-5110-8_18. [DOI] [PubMed] [Google Scholar]
  112. McCarty J.M., Grant C.K. Int. J. Cancer. 1983;31:627–631. doi: 10.1002/ijc.2910310515. [DOI] [PubMed] [Google Scholar]
  113. McCarty J.M., Grant C.K. Cell Immunol. 1983;81:157–168. doi: 10.1016/0008-8749(83)90221-6. [DOI] [PubMed] [Google Scholar]
  114. Mackey L.J., Jarrett W.F.H., Jarrett O., Laird H. J. Natl. Cancer Inst. 1975;54:1–5. doi: 10.1093/jnci/54.1.209. [DOI] [PubMed] [Google Scholar]
  115. McDonough S., Larsen S., Brodey R.S., Stock N.D., Hardy W.D. Cancer Res. 1971;31:953–956. [PubMed] [Google Scholar]
  116. Madewell B.R., Jarrett O. Vet. Rec. 1983;112:339–342. doi: 10.1136/vr.112.15.339. [DOI] [PubMed] [Google Scholar]
  117. Madewell B.R., Holmes P.H., Onions D.E. Am. J. Vet Res. 1983;44:424–427. [PubMed] [Google Scholar]
  118. Mastro J.M., Lewis M.G., Mathes L.E., Sharpee R., Tarr M.J., Olsen R.G. Vet. Immunol. Immunopathol. 1986;11:205–213. doi: 10.1016/0165-2427(86)90001-2. [DOI] [PubMed] [Google Scholar]
  119. Mathes L.E., Olsen R.G., Hebebrand L.C., Hoover E.A., Schaller J.P. Nature (London) 1978;274:687–689. doi: 10.1038/274687a0. [DOI] [PubMed] [Google Scholar]
  120. Mathes L.E., Yohn D.S., Hoover E.A., Essex M., Schaller J.P., Olsen R.G. J. Natl. Cancer Inst. 1986;56:1197–1200. doi: 10.1093/jnci/56.6.1197. [DOI] [PubMed] [Google Scholar]
  121. Mia A.S., Kahn D.E., Tierney M.M., Post J.E. Comp. Immunol. Microbiol. Infect. Dis. 1981;4:111–117. doi: 10.1016/0147-9571(81)90036-9. [DOI] [PubMed] [Google Scholar]
  122. Mochizuki M., Jarrett O. J. Gen. Virol. 1985;66:385–389. doi: 10.1099/0022-1317-66-2-385. [DOI] [PubMed] [Google Scholar]
  123. Moore F.M., Emerson W.E., Cotter S.M., DeLellis R.A. Vet. Pathol. 1986;23:386–391. doi: 10.1177/030098588602300407. [DOI] [PubMed] [Google Scholar]
  124. Mullins J.I., Brody D.S., Binari R.C., Jr., Cotter S.M. Nature (London) 1984;308:856–858. doi: 10.1038/308856a0. [DOI] [PubMed] [Google Scholar]
  125. Mullins J.I., Chen C.S., Hoover E.A. Nature (London) 1986;319:332–336. doi: 10.1038/319333a0. [DOI] [PubMed] [Google Scholar]
  126. Neil J.C., Hughes D., McFarlane R., Wilkie N.M., Onions D.E., Lees G., Jarrett O. Nature (London) 1984;308:856–858. doi: 10.1038/308814a0. [DOI] [PubMed] [Google Scholar]
  127. Niederkorn J.Y., Shadduck J.A., Albert D. Invest. Ophthalmol. Vis. Sci. 1983;23:719–725. [PubMed] [Google Scholar]
  128. Niman H.L., Gardner M.B., Stephenson J.R., Roy-Burman P. J. Virol. 1977;23:578–586. doi: 10.1128/jvi.23.3.578-586.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  129. Nunberg J.H., Williams M.E., Innis M.A. J. Virol. 1984;49:629–632. doi: 10.1128/jvi.49.2.629-632.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Nunberg J.H., Gilbert J.H., Rodgers G., Snead R.M., Nitecki D.E. In: “Modern Approaches to Vaccines”. Channock R., Lerner R., editors. Cold Spring Harbor Press; Cold Spring, New York: 1986. in press. [Google Scholar]
  131. O'Brien S.J. Proc. Natl. Acad. Sci. U.S.A. 1976;73:4618–4622. doi: 10.1073/pnas.73.12.4618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Olsen R.G., Hoover E.A., Mathes L.E., Heding L., Schaller J.P. Cancer Res. 1976;36:3642–3646. [PubMed] [Google Scholar]
  133. Olsen R.G., Hoover E.A., Schaller J.P., Mathes L.E., Wolff L.H. Cancer Res. 1977;37:2082–2085. [PubMed] [Google Scholar]
  134. Onions D., Jarrett O., Testa N.G., Frassoni F., Toth S. Nature (London) 1982;296:156–158. doi: 10.1038/296156a0. [DOI] [PubMed] [Google Scholar]
  135. Onions, D., Testa, N., Warnock, M., Toth, S., and Neil, J. (1985). Symp. Comp. Res. Leuk. Related Dis., 22nd, Hamburg
  136. Orosz C.G., Zinn N.E., Olsen R.G., Mathes L.E. J. Immunol. 1985;135:583–590. [PubMed] [Google Scholar]
  137. Osterhaus A., Weijer K., Uytdehaag F., Jarrett O., Sundquist B., Morein B. J. Immunol. 1985;135:591–596. [PubMed] [Google Scholar]
  138. Pacitti, A., and Jarrett, O. (1986). UCLA Symp. Viruses Hum. Cancer, Park City, Utah.
  139. Pedersen N.C., Ho E.W., Brown M.L., Yamamoto J.K. Science. 1987;235:790–793. doi: 10.1126/science.3643650. [DOI] [PubMed] [Google Scholar]
  140. Perryman L.E., Hoover E.A., Yohn D.S. J. Natl. Cancer Inst. 1972;49:1397–1405. [PubMed] [Google Scholar]
  141. Ras G.J., Eftychis H.A., Anderson R., van der Walt I. S. Afr. Med. J. 1984;66:806–809. [PubMed] [Google Scholar]
  142. Reinacher M. Vet. Pathol. 1987;24:1–4. doi: 10.1177/030098588702400101. [DOI] [PubMed] [Google Scholar]
  143. Rezanka, L. J., Rojko, J. L., and O'Brien, S. J. (1987). In preparation.
  144. Rickard C.G., Post J.E., de Noronha F., Barr L.M. J. Natl. Cancer Inst. 1969;42:987–1014. [PubMed] [Google Scholar]
  145. Riedel, N., Hoover, E. A., Elder, J. A. et al. (1986a). UCLA Mol. Symp. Viruses Hum. Cancer, Park City, Utah, Feb.
  146. Riedel N., Hoover E.A., Gasper P.W., Nicholson M.O., Mullins J.I. J. Virol. 1986;60:242–250. doi: 10.1128/jvi.60.1.242-250.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  147. Rojko J.L. Semin. Vet. Med. Surg. 1986;1:61–67. [PubMed] [Google Scholar]
  148. Rojko J.L., Olsen R.G. Vet. Immunol. Immunopathol. 1984;6:107–165. doi: 10.1016/0165-2427(84)90050-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Rojko J.L., Hoover E.A., Mathes L.E., Olsen R.G., Schaller J.P. J. Natl. Cancer Inst. 1979;63:759–768. doi: 10.1093/jnci/63.3.759. [DOI] [PubMed] [Google Scholar]
  150. Rojko J.L., Hoover E.A., Mathes L.E., Krakowka S., Olsen R.G. Cancer Res. 1979;39:3789–3791. [PubMed] [Google Scholar]
  151. Rojko J.L., Hoover E.A., Finn B.L., Olsen R.G. J. Natl. Cancer Inst. 1981;67:899–910. [PubMed] [Google Scholar]
  152. Rojko J.L., Hoover E.A., Quackenbush S.L., Olsen R.G. Nature (London) 1982;298:385–388. doi: 10.1038/298385a0. [DOI] [PubMed] [Google Scholar]
  153. Rojko J.L., Cheney C.M., Gasper P.W., Hamilton K.L., Hoover E.A., Mathes L.E., Kociba G.J. Leuk. Res. 1986;10:1193–1199. doi: 10.1016/0145-2126(86)90237-7. [DOI] [PubMed] [Google Scholar]
  154. Rojko J.L., Rezanka L.J., Sowder J.T., Cooper M.D., Klotz F.J. J. Natl. Cancer Inst. 1987 submitted. [Google Scholar]
  155. Russell P.H., Jarrett O. Int. J. Cancer. 1978;21:351–357. doi: 10.1002/ijc.2910220320. [DOI] [PubMed] [Google Scholar]
  156. Russell P.H., Jarrett O. Int. J. Cancer. 1978;21:768–788. doi: 10.1002/ijc.2910210615. [DOI] [PubMed] [Google Scholar]
  157. Sacca R., Stanley E.R., Sherr C.J., Rettenmier C.W. Proc. Natl. Acad. Sci. U.S.A. 1986;83:3331–3335. doi: 10.1073/pnas.83.10.3331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  158. Salerno R.A., Lehman E.D., Larson V.M., Hilleman M.R. J. Natl. Cancer Inst. 1978;61:1487–1493. [PubMed] [Google Scholar]
  159. Sariban E., Mitchell T., Kufe D. Nature (London) 1985;316:164–166. doi: 10.1038/316064a0. [DOI] [PubMed] [Google Scholar]
  160. Sarma P.S., Log T. Virology. 1973;54:160–169. doi: 10.1016/0042-6822(73)90125-6. [DOI] [PubMed] [Google Scholar]
  161. Sherr C.J., Sen A., Todaro G.J., Sliski A., Essex M. Proc. Natl. Acad. Sci. U.S.A. 1978;75:1505–1509. doi: 10.1073/pnas.75.3.1505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  162. Sherr C.J., Todaro G.J., Sliski A.H., Essex M. Proc. Natl. Acad. Sci. U.S.A. 1978;75:4489–4493. doi: 10.1073/pnas.75.9.4489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  163. Sliski A.H., Essex M., Meyer C., Todaro G.J. Science. 1977;196:1336–1339. doi: 10.1126/science.194310. [DOI] [PubMed] [Google Scholar]
  164. Snyder S.P., Theilen G.H. Nature (London) 1969;221:1074–1075. doi: 10.1038/2211074a0. [DOI] [PubMed] [Google Scholar]
  165. Snyder H.W., Hardy W.D., Zuckerman E.E., Fleissner E. Nature (London) 1978;275:656–657. doi: 10.1038/275656a0. [DOI] [PubMed] [Google Scholar]
  166. Snyder H.W., Jones F.R., Day N.K., Hardy W.D., Jr. J. Immunol. 1982;128:2726–2730. [PubMed] [Google Scholar]
  167. Snyder H.W., Jr., Singhal M.C., Zuckerman E.E., Jones F.R., Hardy W.D., Jr. Virology. 1983;131:315–327. doi: 10.1016/0042-6822(83)90500-7. [DOI] [PubMed] [Google Scholar]
  168. Stephenson J.R., Khan A.S., Sliski A.H., Essex M. Proc. Natl. Acad. Sci. U.S.A. 1977;74:5608–5612. doi: 10.1073/pnas.74.12.5608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  169. Soe L.H., Shimizu R.W., Landolph J.R., Roy-Burman P. J. Virol. 1985;56:701–710. doi: 10.1128/jvi.56.3.701-710.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Stewart M.A., Warnock M., Wheeler A., Wilkie N., Mullins J.I., Onions D.E., Neil J.C. J. Virol. 1986;58:825–834. doi: 10.1128/jvi.58.3.825-834.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  171. Stewart M.A., Forrest D., McFarlane R., Onions D., Wilkie N., Neil J.C. Virology. 1986;154:121–134. doi: 10.1016/0042-6822(86)90435-6. [DOI] [PubMed] [Google Scholar]
  172. Stiff M.I., Olsen R.G. J. Gen. Virol. 1983;64:957–959. doi: 10.1099/0022-1317-64-4-957. [DOI] [PubMed] [Google Scholar]
  173. Swenson C., Kociba G.J., O'Keefe D., Crisp S., Jacobs R., Rojko J.L. J. Am. Vet. Med. Assoc. 1987;191:93–96. [PubMed] [Google Scholar]
  174. Testa N.G., Onions D., Jarrett O., Frassoni F., Eliason J.F. Leuk. Res. 1983;7:103–116. doi: 10.1016/0145-2126(83)90001-2. [DOI] [PubMed] [Google Scholar]
  175. Tompkins M.B., Cummins J.M. Fel. Pract. 1982;12:6–15. [Google Scholar]
  176. Tompkins M.B., Tompkins W.A. J. Immunol. 1985;135:2817–2823. [PubMed] [Google Scholar]
  177. Trainin Z., Wernicke D., Unger-Waron H., Essex M. Science. 1983;220:858–859. doi: 10.1126/science.6302837. [DOI] [PubMed] [Google Scholar]
  178. Tuomari D.L., Olsen R.G., Singh V.K., Kraut E.H. Vet. Immunol. Immunopathol. 1984;7:227–238. doi: 10.1016/0165-2427(84)90081-3. [DOI] [PubMed] [Google Scholar]
  179. Twardzik D.R., Todaro G.J., Reynolds F.H., Stephenson J.R. Virology. 1983;124:201–207. doi: 10.1016/0042-6822(83)90307-0. [DOI] [PubMed] [Google Scholar]
  180. Valli V.E., McSherry B.J., Dunham B.M., Jacobs R.M., Lumsden J.H. Vet. Pathol. 1981;18:494–512. doi: 10.1177/030098588101800408. [DOI] [PubMed] [Google Scholar]
  181. Vedbrat S.S., Rasheed S., Lutz H., Gonda M.A., Ruscetti S., Gardner M.B., Prensky W. Virology. 1983;124:445–461. doi: 10.1016/0042-6822(83)90360-4. [DOI] [PubMed] [Google Scholar]
  182. Weijer K., Uytdehaag F.G., Jarrett O., Osterhaus A.D. Int. J. Cancer. 1986;38:81–87. doi: 10.1002/ijc.2910380114. [DOI] [PubMed] [Google Scholar]
  183. Weiser M.G., Kociba G.J. Vet. Pathol. 1983;20:687–697. doi: 10.1177/030098588302000604. [DOI] [PubMed] [Google Scholar]
  184. Weller S.K., Joy A.E., Temin H.M. J. Virol. 1980;33:494–506. doi: 10.1128/jvi.33.1.494-506.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  185. Wellman M.L., Kociba G.J., Lewis M.G., Mathes L.E., Olsen R.G. Cancer Res. 1984;44:1527–1529. [PubMed] [Google Scholar]
  186. Wernicke D., Trainin Z., Unger-Waron H., Essex M. J. Virol. 1986;60:669–673. doi: 10.1128/jvi.60.2.669-673.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  187. Whisler R.L., Lewis M.G., Olsen R.G., Basu S.K. Cancer Res. 1987 submitted. [Google Scholar]
  188. Wolff L.H., Mathes L.E., Olsen R.G. J. Immunol. Methods. 1979;26:151–156. doi: 10.1016/0022-1759(79)90078-4. [DOI] [PubMed] [Google Scholar]
  189. Wong T.C., Goodenow R.S., Sher B.T., Davidson N. Gene. 1985;34:27–38. doi: 10.1016/0378-1119(85)90291-4. [DOI] [PubMed] [Google Scholar]
  190. Yohn D.S., Olsen R.D., Schaller J.P., Hoover E.A., Mathes L.E., Heding L., Davis G.W. Cancer Res. 1976;36:646–651. [PubMed] [Google Scholar]
  191. Youngren S.D., Vukasin A.P., de Noronhaf Cancer Res. 1984;44(8):3512–3517. [PubMed] [Google Scholar]

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