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. Author manuscript; available in PMC: 2020 Jun 4.
Published in final edited form as: Atherosclerosis. 2011 Aug 6;220(1):45–52. doi: 10.1016/j.atherosclerosis.2011.07.095

Fig. 3.

Fig. 3.

(A) VSMC from AIF-1 transgenic mice migrate more rapidly in response to ox-LDL. VSMC from transgenic and wild-type mice were seeded into Boyden chambers, and differences in chemotaxis quantitated by counting cells which migrated in response to 30 μg/ml ox-LDL and in serum-free media compared with wild-type VSMC from matched controls (P < 0.01). Data shown from at least three independently performed experiments. (B and C) VSMC from AIF-1 transgenic mice express significantly increased MMP2 and MMP9 mRNA compared with control VSMC (P < 0.01 or 0.001 for all time points) quantitated by quantitative RT-PCR. (D) MMP2 and MMP9 protein is increased in VSMC from AIF-1 transgenic mice compared with control VSMC. Lysates from untreated and ox-LDL stimulated VSMC were immunoblotted with the antibodies shown. Western Blot shown is representative of at least three.