Figure 3. Mediation of neocortical amyloid and memory by EC tau and presubiculum volume is contingent on hippocampal amyloid.

(A) Total effect of neocortical amyloid predicting memory. (B) Mediation by entorhinal cortex (EC) tau and (C) secondary mediation by presubiculum volume. (D) Moderated mediation model. All β values are standardized estimates. (E) Conditional effect by which hippocampal amyloid moderates the mediation of EC tau binding on presubiculum volume. The plot shows that, at higher levels of hippocampal amyloid, the relationship between EC tau and presubiculum volume is more negative compared to lower levels of hippocampal amyloid deposition. Green arrows indicate the significant paths resulting in mediation/moderation. *p < 0.05; **p < 0.01; ***p < 0.001.