Figure 2.

Characteristic structural features of C‐type lectins. A) Cartoon representation of five representative CLRs belonging to five different C‐type lectin groups (II, III, IV, V and VI).[ ⁶ , ¹⁰ ] B) Structural comparison between the CRDs of the same five lectins: human langerin (PDB ID: 5G6U), human surfactant protein D (PDB ID: 4E52), human L‐selectin (PDB ID: 3CFW), murine dectin‐1 (PDB ID: 2CL8), and human macrophage mannose receptor 1 (CRD2, PDB ID: 5XTS). Calcium ions are depicted in each case. C) Common structural motifs present in the CTLD fold (model: DC‐SIGN CRD, PDB ID: 1SL5). Right: the main secondary structure elements; left: typical conserved residues among different CTLDs and species. Calcium ions are shown as black spheres.[ ^7a , ¹¹ ]