Pavan Kumar Prathipati1, Subhra Mandal1, Gregory Pon1, Renuga Vivekanandan2, Christopher J. Destache1,2
There are errors in the published article (Volume 34, Number 12, pp. 2749–2755).
The errors occurred in pharmacokinetic study design of materials and methods section on page 2750–51.
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Another group of 15 mice (3 mice/time point) were injected SubQ with 200 mg/kg (each TAF, FTC, and EVG) of free drug in 1 mL of 5% dextrose.
FTC is not related to the objective of this article and it has no reported drug-drug interactions that could affect PK of TAF and EVG [1].
References- AIDSinfo, Drug Interactions between Nucleoside Reverse Transcriptase Inhibitors and Other Drugs (Including Antiretroviral Agents). in: U.S.D.o.H.H. Services (Ed.), U.S. Department of Health & Human Services, Washington, DC, USA, 2018.
Institutional Animal Care and Use Committee approved protocol (#0989) and procedures were followed. However, the authors retrospectively found that “injecting naïve TAF+FTC+EVG solution to mice” was not in the approved protocol.
Footnotes
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