Table 3.
Examples of different therapeutic nucleic acids delivered by silica-based nanocarriers.
| Nucleic Acid | Carrier Type | NA Location | Loading Strategy | Cell Line(s) | In Vivo | Application | Reference |
|---|---|---|---|---|---|---|---|
| DNA | |||||||
| pDNA | MSNs | Surface | Adsorption | Neuro-2A | None | Cancer | [146] |
| pDNA | MSNs | Surface | Adsorption | HEPA-1 | None | Cancer | [147] |
| dsDNA | MSNs | Surface | Adsorption | HeLa | None | Cancer | [148] |
| dsDNA | MSNs | Surface | Adsorption | HL-60 | None | Cancer | [149] |
| pDNA | IDMSMs | Surface | Adsorption | QGY-7703 | Mice | Cancer | [150] |
| ssDNA | MSNs | Surface | Disulfide bond Maleimide |
MCF-7 | None | Cancer | [151] |
| dsDNA | HMSNs | Surface | Adsorption | MCF-7, A549, HepG2 | None | Cancer | [152] |
| ssDNA | MSNs | Surface | Adsorption | MDA-MB-231 | Mice | Cancer | [153] |
| ssDNA | MSNs | Surface | Adsorption | MCF-7, K-562, U2OS | Mice | Cancer | [154] |
| pDNA | MSNs | Surface | Adsorption | 293T, RAW264.7 | Mice | Hepatitis B | [155] |
| siRNA | |||||||
| PKM2 | MSNs | Surface | Adsorption | MDA-MB-231 | Mice | Cancer | [156] |
| Cell-killing | MSNs | Mesopores | Adsorption | MDA-MB-231 | None | Cancer | [157] |
| HER2 | MSNs | Surface | Adsorption | BT474 | None | Cancer | [158] |
| TGFβR-1 | MSNs | Surface | Adsorption | RT3 | Mice | Cancer | [159] |
| MDR1 | MSNs | Surface | Adsorption | CAL27 | None | Cancer | [160] |
| MDR1 | MSNs | Surface | Adsorption | KBV | Mice | Cancer | [161] |
| Bcl-2 | MSNs | Surface | Adsorption | SKOV-3, MCF-7 | None | Cancer | [162] |
| Bcl-2 | MSNs | Surface | Adsorption | SKOV-3 | Mice | Cancer | [163] |
| TWIST | MSNs | Surface | Adsorption | F2, Ovcar8 | Mice | Cancer | [164] |
| VEGF | MSNs | Surface | Adsorption | HeLa, HepG2 | None | Cancer | [165] |
| VEGF | MSNs | Surface | Adsorption | HepG2, Huh7 | None | Cancer | [166] |
| HSP47 | MSNs | Surface | Adsorption | PMDF | Mice | Fibrosis | [167] |
| TnC | MSNs | Surface | Adsorption | rHSCs, mHSCs | None | Fibrosis | [168] |
| COLL1A1 | MSNs | Surface | Adsorption | HDFs | Rat | Tissue regeneration | [169] |
| SOST | MSNs | Surface | Adsorption | MEF, HeLa | Mice | Osteoporosis | [170] |
| miRNA | |||||||
| miR-155 | MSNs | Mesopores | Adsorption | SW480 | Mice | Cancer | [171] |
| miR-328 | MSNs | Mesopores | Adsorption | SW480, SW620, HT-29, Lovo, Caco-2 | Mice | Cancer | [172] |
| miR-34a miR-10b |
MSNs | Mesopores | Adsorption | MDA-MB-231, MDA-MB-468 | Mice | Cancer | [173] |
| miR-26a | MSNs | Mesopores | Adsorption | rBMSCs | None | Tissue regeneration | [174] |
| miR-200c siPlk1 |
MSNs | Mesopores | Adsorption | MDA-MB-231 | Mice | Cancer | [175] |
Abbreviations: IDMSN: imidazole dendritic mesoporous silica nanoparticles; PKM2: glycolytic enzyme pyruvate kinase; HER2: human epidermal growth factor receptor 2; TGFβR-1: transforming growth factor, beta receptor I; MDR1: multidrug resistance protein 1; Bcl-2: B-cell lymphoma 2; VEGF: vascular endothelial growth factor; HSP47: heat-shock protein 47; TnC: tenascin-C; COLL1A1: collagen type I; PMDFs: primary mouse dermal fibroblasts; HSCs: human stem cells; HDFs: human dermal fibroblasts; MEF: mouse embryonic fibroblastic cells; rBMSCs: rat bone marrow stromal cells.