Table 1.

Regulation of senescence-associated secretory phenotype (SASP) and autophagy by polyphenols.

Polyphenols	Anti-SASP	Autophagy
Resveratrol	Mitigates the Inflammatory phenotype in senescent human fibroblast [147]	Upregulation of autophagic pathways in HUVECs treated by hydrogen peroxide [150]
Resveratrol	Down-regulation of SASP-associated proinflammatory cytokines IL-8 and TNFα, and up-regulation of anti-inflammatory cytokine IL-10 in gut of the fish Nothobranchius guentheri [149]	Restoration of autophagic flux in muscle cells after palmitate-induced cellular senescence [151]
Epigallocatechin gallate	The suppression of SASP in preadipocytes treated by hydrogen peroxide [152]	Activation of autophagy through a CaMKKβ/AMPK-dependent mechanism and support autophagic flux in BAEC [153]
Apigenin	Reduction of SASP in BJ cells treated with bleomycin and the kidney of aged rats [154]	Amentoflavone (dimer composed of apigenin) caused induction of autophagy in A549 and WI-38 cells trated by the treatment with insulin- like growth factor-1 (IGF-1) [155]
Quercetin	Decreasing of SASP components in BJ cells treated with bleomycin [154]	Upregulation of MST1-mediated autophagy in RAW264.7 macrophages treated by oxidized low-density lipoprotein [156]