Fig. 5.

Male βMcu-KO mice display slightly improved glucose tolerance. Glucose tolerance was measured in βMcu-KO mice and littermate controls (WT) by IPGTT (1 g/kg body weight) at (a,b) 8, (c,d) 12, (e,f) 16 and (g,h) 24 weeks of age. The corresponding AUC is shown for each graph (n = 8–14 mice per genotype in four or five independent experiments). Blue, WT mice; red, βMcu-KO mice. Islets were isolated from 8–10-week-old male mice maintained on standard chow diet. Data are presented as mean ± SEM. *p< 0.05; **p< 0.01; ***p< 0.001 as indicated or WT vs KO mice at the time points indicated, analysed by two-way ANOVA test