Table 4.

Top five gene networks of DEGs induced by butyrate detected in bulk cell RNA sequencing.

ID	Genes in Network	Focus Molecules	Top Functions
1	AMY2B,AURKA, CCNB1,Cdc2,CDC25B,CENPU,CEP55,CIT,E2F1,ECT2,ERCC6L, Gamma tubulin, GINS1,GM2A,KIF23,KIF2C,KIF4A,KIFC1,MTHFD1,NCAPD3,NCAPG, NCAPG2,NCAPH,NDC80,PLK1, POLA2,PRC1,RACGAP1,SGO2,SMC2,SMC4,TACC3,TRPV2,UHRF1,ZYG11A	33	Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair
2	ADGRL3,APBA2,BIRC5,CDCA8,CHGA, CHGB,CLMN,CPE,Creb,CYP17A1,EMX2,ESPL1,GDPD3,GPBAR1, GPR85,GSTM3,GZMM, Hdac,KCNH2,KLF9,NTRK1,ONECUT2,OTX1,OXT,PAX2,PCSK1,PSMC3IP,RET, SHANK1,SLC5A8,SSTR2,TRAIP,WNT1,WNT4,WNT9B	33	Embryonic Development, Organ Development, Organismal Development
3	ATAD5,AURKB, BARD1,BLM,BRCA1,BRCA2,BRIP1,CHEK2,CHTF18,DNA2,DSCC1,DTL,FANCB, FANCG, FEN1,FIGNL1,I kappa b kinase, Igm, MCM8,PALB2,PARPBP, PCLAF,PCNA, POLH,RAD18,RAD51,RAD54B, RAD54L,RECQL4,RFC3,RFC4,RPA,SMC1A,TOPBP1,XRCC2	32	Cell Cycle, DNA Replication, Recombination, and Repair, Cell Morphology
4	ADGRF5,ADORA2A,ATP2B3,C3,CENPE, CENPF,CFB,CFD,COCH, Collagen type II, CXCL2, CXCL3, DSN1,FBL,GABRB3,GNG7,GNL3,GPLD1,HRH3,MAC,MST1R,NPHS1,NPM1,NUF2,OGG1,Pde4,PMF1/PMF1-BGLAP, SERPING1, SPC24,SPC25, ST14, SYT11,TNNI1,TNNI3,ZWINT	32	Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair
5	ABCG5,ACACB,C2,CBLC, CIDEB,CLCA1,CREB3L3,CYP11A1,CYP2F1,DHH,EBF1,ELOVL3,ENO2,FBP2,FLT4,FOXA3, GGT1,GGT5,GRIN2C,ITGA9, KCP,LCN2,MLXIPL,MMP15,Mucin,Nr1h,OSTN, PEPCK,PPARGC1A,RORA, RORC,SERPINF1,SLC29A4,SYT2,SYT7	32	Metabolic Disease, Lipid Metabolism, Small Molecule Biochemistry