Table 5.
Regulator effects: genes significantly changed by two key upstream regulators E2F1 and TGFB1.
| Gene name | Description | Log₂ fold change | P value | FDR P value |
|---|---|---|---|---|
| CCND1 | cyclin D1 | -1.15 | 0 | 0 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.74 | 0 | 0 |
| CHGA | chromogranin A | 3.41 | 0 | 0 |
| E2F1 | E2F transcription factor 1 | -2.93 | 5.25E-11 | 2.94E-10 |
| E2F4 | E2F transcription factor 4 | -0.75 | 6.72E-12 | 4.01E-11 |
| FOXO1 | forkhead box protein O1 | 1.02 | 3.13E-05 | 1.07E-04 |
| NTRK1 | neurotrophic receptor tyrosine kinase1 | 5.59 | 0 | 0 |
| ONECUT2 | one cut homeobox 2 | 3.12 | 7.17E-03 | 0.02 |
| OXT | oxytocin/neurophysin I prepropeptide | 5.31 | 0.000963 | 0.00272 |
| PAX2 | paired box 2 | 4.73 | 0.01 | 0.03 |
| TGFB1 | transforming growth factor beta 1 | -2.63 | 0 | 0 |
| TP53 | tumor protein p53 | -1.62 | 0 | 0 |
| RARA | retinoic acid receptor alpha | 0.96 | 0 | 0 |
| WNT1 | Wnt family member 1 | 6.59 | 1.47E-06 | 5.77E-06 |
| WNT4 | Wnt family member 4 | 5.86 | 9.30E-05 | 3.30E-03 |