Table 1.
CI and DRI of BEZ235 and Regorafenib combination in HCC.
| Concentration | Hep3B | DRI | |||
| BEZ235 (nM) | Regorafenib (μM) | fa | CI | BEZ235 | Regorafenib |
| 125 | 5 | 0.46 | 1.04 | 3.46 | 1.34 |
| 250 | 5 | 0.54 | 0.99 | 2.53 | 1.68 |
| 500 | 5 | 0.59 | 1.13 | 1.61 | 1.94 |
| Concentration | HepG2 | DRI | |||
| BEZ235 (nM) | Regorafenib (μM) | fa | CI | BEZ235 | Regorafenib |
| 250 | 1 | 0.52 | 0.43 | 8.59 | 3.16 |
| 500 | 1 | 0.56 | 0.48 | 4.75 | 3.70 |
| 1000 | 1 | 0.69 | 0.45 | 3.38 | 6.42 |
| Concentration | Huh7 | DRI | |||
| BEZ235 (nM) | Regorafenib (μM) | fa | CI | BEZ235 | Regorafenib |
| 10 | 2.5 | 0.44 | 0.88 | 3.13 | 1.77 |
| 20 | 2.5 | 0.55 | 0.74 | 2.67 | 2.74 |
| 40 | 2.5 | 0.67 | 0.63 | 2.47 | 4.53 |
Abbreviation: CI, combination index; DRI, dose reduction index; fa, fraction affected.