Table 2.
Bugs as drugs.
| Bug | Animal Model | Mode of Action | Reference |
|---|---|---|---|
| Lactobacillus reuteri | FVB strain Her2 | Inhibits mammary tumorigenesis by CD4+CD25+ lymphocyte stimulation | [13] |
| Swiss mice | |||
| Lactobacillus casei CRL431 | 4T1 syngeneic breast cancer model in Balb/C mice | Inhibits tumor growth, vascularization and lung metastasis in mice by reducing infiltration of macrophages into the tumor and; enhances CD4+ and CD8+ antitumor immune response | [220] |
| Lactobacillus casei | 4T1 syngeneic breast cancer model in Balb/C mice | Reduces breast cancer incidence | [216] |
| Shirota | |||
| Lactobacillus acidophilus | 4T1 syngeneic breast cancer model in Balb/C mice | Improves survival of breast tumor bearing mice | [20] |
| Increased immune cell proliferation | |||
| Increased IFNγ production | |||
| Decreased IL4 production | |||
| Lactobacillus brevis | 4T1 syngeneic breast cancer model in Balb/C mice | Inhibits metastasis to vital organs | [215] |
| Improves NK cell activity | |||
| Increased IFN-γ | |||
| Increased IL-17 levels |