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. 2020 Apr 29;9(5):1103. doi: 10.3390/cells9051103

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Abnormal ovarian development in XX Wnt4 mutants is independent of SOX9 function. (A–D) Immunodetection of the differentiation marker AMH (green) and the pre-granulosa cell marker FOXL2 (red) in E17.5 XX gonads of Control (A), Sox9^cKO (B), Wnt4^KO (C) and Sox9^cKO Wnt4^KO (D) genotypes. (E–H) Immunodetection of the quiescent cell marker P27 (green) and the germ cell marker TRA98 (red) in E17.5 XX gonads of Control (E), Sox9^cKO (F), Wnt4^KO (G) and Sox9^cKO Wnt4^KO (H) genotypes. (I–L) Immunodetection of the steroidogenic enzyme HSD3β (green) and the steroidogenic transcription factor NR5A1 (red) in E17.5 XX gonads of Control (I), Sox9^cKO (J), Wnt4^KO (K), and Sox9^cKO Wnt4^KO (L) genotypes. Nuclei labeled with DAPI are shown in blue. Magnification is the same in all panels. Scale bar = 100 μm.