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. 2020 May 18;10(15):6728–6742. doi: 10.7150/thno.42259

Figure 2.

Figure 2

UMSC-Exo enhances ischemic muscle repair by up regulating circHIPK3. (A) RT-PCR analysis of circHIPK3 expression in ischemic muscle and control. (B) RT-PCR analysis of circHIPK3 expression in UMSC and UMSC-Exo. (C) RT-PCR analysis of circHIPK3 expression in ischemic muscle that were treated with PBS, UMSC-Exo, or Exo-si-circHIPK3. (D) Laser Doppler perfusion imaging of limbs from mice in different treatment groups after ischemic surgery. (E) Blood flow recovery after ischemic surgery. (F) Muscle force. (G) Running distance. Data is shown as mean ± standard deviation (n=3). *P <0.05, **P <0.01, ***P <0.001.