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. 2020 May 25;10(15):6959–6976. doi: 10.7150/thno.41792

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SC144 induces hypoxia in LNCaP cells. (A) Top 25 upregulated gene set overlapping by SC144 between OVCAR-8 and LNCaP cells. (B) Top 10 gene sets positively associated with SC144 treatment in LNCaP cells. Gene sets with FDR q-value lower than 0.25 are considered true enrichment. (C) Enrichment plots of hallmark HYPOXIA gene set over-represented most significantly out of the pre-ranked gene lists from SC144 treatment in LNCaP cells. (D) Synthesis of HIF1A-AS2 nascent RNA is up-regulated by SC144 in LNCaP cells. (E) Overlapping of positively correlated compounds with SC144 analysed by cMap between SC144 OVCAR-8 and LNCaP cells. Compounds with a median score >90 are considered.