doi: 10.1093/toxsci/kfv243
Toxicological Sciences 149(2),411–432, 2016
Upon further review of Supplementary Table 1, the authors identified that some data were erroneously swapped when reporting. The corrected table is available online.
This error has no impact on the overall validity or conclusion of the study.
The authors regret this error.
Supplementary Table 1. Yields per cigarette of selected 3R4F mainstream smoke and THS aerosol constituents (HPHCs).
A. Normalized for nicotine levels, analysis from a THS2.2 batch used in this study (3R4F was measured in a previous study but is considered representative of the actual batches used during this study).
| ISO parameters | THS2.2 | 3R4F | |
|---|---|---|---|
| 1. Carbon monoxide | mg/mg nicotine | 0.437 ± 0.031 | 14.8 ± 0.715 |
| 2. Nicotine | mg/mg nicotine | 1 ± 0.045 | 1 ± 0.0542 |
| 3. Tar | mg/mg nicotine | 6.304 ± 1.214 | 14.3 ± 0.717 |
| 4. TPM | mg/mg nicotine | 34.72 ± 1.396 | 22.2 ± 1.2 |
| 5. Water | mg/mg nicotine | 27.41 ± 1.937 | 7.01 ± 0.673 |
| Aliphatic dienes | |||
| 6. 1,3-Butadiene | µg/mg nicotine | 0.298 ± 0.053 | 36.7 ± 3.6 |
| 7. Isoprene | µg/mg nicotine | 2.483 ± 0.335 | 427 ± 36.4 |
| Carbonyls | |||
| 8. Acetaldehyde | µg/mg nicotine | 157.9 ± 15.78 | 719 ± 50.1 |
| 9. Acetone | µg/mg nicotine | 29.35 ± 3.463 | 323 ± 11.9 |
| 10. Acrolein | µg/mg nicotine | 8.165 ± 1.189 | 77 ± 5.51 |
| 11. Butyraldehyde | µg/mg nicotine | 20.32 ± 2.024 | 41.7 ± 3.64 |
| 12. Crotonaldehyde | µg/mg nicotine | 2.809 ± 0.333 | 40.5 ± 4.31 |
| 13. Formaldehyde | µg/mg nicotine | 2.623 ± 0.271 | 28.3 ± 3.48 |
| 14. Methyl ethyl ketone | µg/mg nicotine | 5.986 ± 0.91 | 91.9 ± 5.79 |
| 15. Propionaldehyde | µg/mg nicotine | 11.75 ± 1.483 | 58.1 ± 2.68 |
| Acid derivatives | |||
| 16. Acetamide | µg/mg nicotine | 3.063 ± 0.283 | 7.17 ± 0.399 |
| 17. Acrylamide | µg/mg nicotine | 1.918 ± 0.188 | 2.03 ± 0.157 |
| 18. Acrylonitrile | µg/mg nicotine | 0.166 ± 0.013 | 14.4 ± 0.894 |
| Epoxides | |||
| 19. Ethylene oxide | µg/mg nicotine | 0.167 ± 0.011 | 12.9 ± 0.998 |
| 20. Propylene oxide | µg/mg nicotine | 0.094 ± 0.008 | 0.723 ± 0.0234 |
| Nitro compounds | |||
| 21. Nitrobenzene | N.D. | N.D. | |
| Aromatic Amines | |||
| 22. 1-Aminonaphthalene | ng/mg nicotine | 0.065 ± 0.007 | 9.95 ± 0.6 |
| 23. 2-Aminonaphthalene | ng/mg nicotine | 3/4 < 0.024 | 5.11 ± 0.186 |
| 24. 3-Aminobiphenyl | ng/mg nicotine | 0.043 ± 0.005 | 1.64 ± 0.213 |
| 25. 4-Aminobiphenyl | ng/mg nicotine | 4/4 < 0.032 | 1.31 ± 0.115 |
| 26. o-Toluidine | ng/mg nicotine | 0.962 ± 0.076 | 43.5 ± 1.45 |
| 27. Benzidine | ng/mg nicotine | 4/4 < 7E-4 | N.D. |
| N-Heterocyclic aromatics | |||
| 28. Pyridine | µg/mg nicotine | 6.343 ± 0.283 | 18 ± 0.833 |
| 29. Quinoline | µg/mg nicotine | 0.016 ± 0.001 | 0.273 ± 0.0276 |
| Halogen compounds | |||
| 30. Vinyl chloride | ng/mg nicotine | 4/4 < 2.477 | 50.2 ± 2.75 |
| Inorganic compounds | |||
| 31. Ammonia | µg/mg nicotine | 10.18 ± 0.611 | 19.4 ± 0.847 |
| 32. Hydrogen cyanide | µg/mg nicotine | 2.905 ± 0.201 | 215 ± 17.2 |
| 33. Nitric oxide | µg/mg nicotine | 11.37 ± 0.521 | 218 ± 10.3 |
| 34. Nitrogen oxides | µg/mg nicotine | 11.48 ± 0.516 | 240 ± 12.3 |
| Monocyclic aromatics | |||
| 35. Benzene | µg/mg nicotine | 0.538 ± 0.037 | 46.8 ± 1.7 |
| 36. Styrene | µg/mg nicotine | 0.578 ± 0.048 | 11.9 ± 0.497 |
| 37. Toluene | µg/mg nicotine | 2.172 ± 0.231 | 97.8 ± 3.8 |
| N-nitrosamines | |||
| 38. N-Nitrosoanabasine (NAB) | ng/mg nicotine | 4/4 < 2.173 | 18 ± 1.24 |
| 39. N-Nitrosoanatabine (NAT) | ng/mg nicotine | 11.67 ± 1.224 | 173 ± 10.1 |
| 40. 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) | ng/mg nicotine | 4.631 ± 0.387 | 117 ± 5.56 |
| 41. N-Nitrosonornicotine (NNN) | ng/mg nicotine | 10.37 ± 1.039 | 155 ± 4.31 |
| Phenols | |||
| 42. Catechol | µg/mg nicotine | 15.53 ± 1.698 | 43.8 ± 2.17 |
| 43. m+p-cresol | µg/mg nicotine | 0.123 ± 0.02 | 6.04 ± 0.448 |
| 44. o-cresol | µg/mg nicotine | 0.102 ± 0.014 | 2.08 ± 0.18 |
| 45. Hydroquinone | µg/mg nicotine | 6.614 ± 0.859 | 40.2 ± 1.85 |
| 46. Phenol | µg/mg nicotine | 1.617 ± 0.269 | 6.59 ± 0.497 |
| 47. Resorcinol | µg/mg nicotine | 0.049 ± 0.004 | 0.894 ± 0.0364 |
| PAHs | |||
| 48. Benzo[a]pyrene | ng/mg nicotine | 3/4 < 0.696 | 4.66 ± 1.87 |
| 49. Benz[a]anthracene | ng/mg nicotine | 1.078 ± 0.051 | 9.21 ± 3.19 |
| 50. Dibenz[a,h]anthracene | ng/mg nicotine | 4/4 < 0.07 | 3/8 < 0 |
| 51. Pyrene | ng/mg nicotine | 4.085 ± 0.24 | 25.5 ± 15.2 |
| Metals/Elements | |||
| 52. Arsenic | ng/mg nicotine | 3/3 < 0.787 | 3.32 ± 0.209 |
| 53. Cadmium | ng/mg nicotine | 0.371 ± 0.008 | 63.7 ± 3.28 |
| 54. Chromium | ng/mg nicotine | 3/3 < 0.118 | 4/4 < 0.257 |
| 55. Lead | ng/mg nicotine | 3/3 < 2.332 | 14.8 ± 0.773 |
| 56. Mercury | ng/mg nicotine | 1.024 ± 0.105 | 1.86 ± 0.0981 |
| 57. Nickel | ng/mg nicotine | 2/3 < 0.118 | 4/4 < 0.257 |
| 58. Selenium | ng/mg nicotine | 3/3 < 0.383 | 0.687 ± 0.126 |
B. Total weights per chemical classes, manufacturer’s specifications.
| Chemical class | Unit weight per stick | Total weight | % reduction | |
|---|---|---|---|---|
| 3R4F | THS2.2 | |||
| Carbon monoxide | mg | 32.8 | 0.531 | 98.4% |
| Carbonyls | µg | 2970.7 | 328.45 | 88.9% |
| Nitrogen oxides | µg | 1028 | 34.1 | 96.7% |
| Aliphatic dienes | µg | 861.8 | 2.644 | 99.7% |
| Inorganic compounds | µg | 532.3 | 19.01 | 96.4% |
| Monocyclic aromatic HC | µg | 310.1 | 3.847 | 98.8% |
| Phenols | µg | 206.62 | 25.771 | 87.5% |
| Acid derivatives | µg | 50.63 | 6.008 | 88.1% |
| N-Heterocyclic aromatics | µg | 36.613 | 7.552 | 79.4% |
| Epoxides | µg | 30.72 | 0.349 | 98.9% |
| TSNA | ng | 926.7 | 47.52* | 94.9% |
| Elements | ng | 214.03 | 7.65* | 96.4% |
| PAHs | ng | 131.2 | 7.55* | 94.2% |
| Aromatic amines | ng | 124.33 | 1.466* | 98.8% |
| Halogen compounds | ng | 96.7 | 3.54* | 96.3% |
| Nitro compounds | ng | 0.499 | 0.09 | 82.0% |
*Measurement replaced by lower limit of quantification.
Remarks: Smoke/aerosol generation according to Health Canada regimen (Burnset al., 2008). These numbers are provided to illustrate the reduction in HPHCs per chemical class and were derived from later product batches.