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Stopping boundaries
| Interim analysis | Number of primary outcome events (information fraction) | Stopping boundaries | |||
|---|---|---|---|---|---|
| Superiority | Futility | ||||
| Hazard ratio | P-value | Hazard ratio | P-value | ||
| 1 | 800 (50%) | < 0.768 | < 0.0002 | > 0.979 | > 0.758 |
| 2 | 1200 (75%) | < 0.806 | < 0.0002 | > 0.931 | > 0.216 |
| Final | 1600 (100%) | < 0.906 | < 0.0500 | ||
Adapted from Pocock et al. [195]; primary outcome events are cardiovascular deaths, myocardial infarction, or ischaemic stroke
