Table 6. GRB7 protein location (cytoplasmic vs. cytoplasmic + membrane accentuated) and clinico-pathological characteristics in 225 patients with invasive ductal carcinoma of the breast.

			GRB7 location				Chi-squared
Clinical factor	Categories	Cyto	%	Cyto + Memb	%	Total	p-value
Tumor size	<2	9	5.33	2	3.57	11	0.5978
	≥2	160	94.67	54	96.43	214
	total	169		56		225
Nodes	Neg	109	64.50	45	80.36	154	0.0269
	Pos	60	35.50	11	19.64	71
	total	169		56		225
HER-2	Neg	47	27.98	2	3.57	49	0.0002
	Equiv	18	10.71	4	7.14	22
	Pos	103	61.31	50	89.29	153
	total	168		56		224
ER	Neg	97	58.08	38	70.37	136	0.1142
	Pos	70	41.92	16	29.63	86
	total	168		54		222
PR	Neg	113	67.26	44	81.48	157	0.0458
	Pos	55	32.74	10	18.52	65
	total	168		54		222

Descriptive frequency and univariate chi-square p-values for patients with cytoplasmic expression (Cyto) vs. patients with cytoplasmic expression and membrane accentuation (Cyto + Memb). Positive GRB7 expression includes 1+, 2+ and 3+. Neg = negative, Pos = positive, Equiv = equivocal. Not all data points were available for all patients.