TABLE 2.
Number of HLA proteins binding at different affinity levels or not binding 0, ≥100 or ≥99% of SARS‐CoV‐2 peptides
| HLA loci (total # of proteins) | ||||||
|---|---|---|---|---|---|---|
| Affinity levels | # peptides | A (92) | B (164) | C (55) | DRB1 (94) | DQA1/DQB1 (34) |
| Strong binding (IC50 ≤ 50 nM) | 0 (%) | 1 (1.1) | 30 (18.3) | 11 (20) | 45 (47.9) | 32 (88.9) |
| ≥ 100 (%) | 17 (18.5) | 5 (3) | 0 (0) | 6 (6.4) | 0 (0) | |
| Regular binding (50 nM < IC50 ≤ 500 nM for Class I) (50 nM < IC50 ≤ 1000 nM for Class II) | 0 (%) | 0 (0) | 2 (1.2) | 5 (9.1) | 0 (0) | 1 (2.9) |
| ≥ 100 (%) | 57 (62) | 41 (25) | 27 (49.1) | 92 (97.9) | 25 (73.5) | |
| Weak binding (500 nM < IC50 ≤ 5000 nM for Class II) (1000 nM < IC50 ≤ 5000 nM for Class II) | 0 (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| ≥ 100 (%) | 92 (100) | 154 (93.9) | 49 (89.1) | 94 (100) | 33 (97.1) | |
| No binding (IC50 > 5000 nM) | 0 (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| ≥ 100 (%) | 92 (100) | 164 (100) | 55 (100) | 94 (100) | 34 (100) | |
| Weak or no binding (IC50 > 500 nM for Class I) (IC50 > 1000 nM for Class II) | 0 (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| ≥99% (%) | 21 (22.8) | 94 (57.3) | 21 (38.2) | 2 (2.1) | 7 (20.6) | |