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Inhibition of S6K1 and PTK by A77 1726. IPEC-DQ (A, C, E) and Vero cells (B, D, F) were left uninfected (A, B, E, F) or infected with 0.5 MOI PEDV (C & D). The cells were then incubated in the absence or presence of the indicated concentrations of A77 1726 for 12 h (A, C, E) or 24 h (B, D, F). The cell lysates were analyzed for the levels of JAK1, JAK2, STAT3, and Src phosphorylation by Western blot (A-D) or for total protein tyrosine phosphorylation (E & F).
