Abstract
An extensive review of new resources to support the provision of evidence-based care for women and infants. The current column includes a discussion of whether it is ethical not to offer doula care to all women, and commentaries on reviews focused on folic acid and autism spectrum disorder, and timing of influenza vaccination during pregnancy.
A review of new resources to support the provision of evidence-based care for women and infants.

Marit L. Bovbjerg, PhD, MS
The Questionable Ethics Behind Lack of Universal Doula Care in the United States
At the end of January, the Centers for Disease Control and Prevention published the U.S. maternal mortality rate for the first time in 13 years (Hoyert & Minino, 2020). The reasons behind the lapse in reporting have been documented (Hoyert and Minino, 2020, MacDorman et al., 2016) and are primarily related to the fact that the United States does not require all states to use the same birth and death certificates. Nonetheless, the newly-published data reveal what many of us had long suspected: the United States has a higher maternal mortality rate than all other high-resource countries (17.4/100,000), and the rate for Black women is much higher (37.1/100,000; Hoyert & Minino, 2020).
In addition to elevated rates of maternal mortality, communities of color in the United States have poorer birth outcomes generally. For instance, women of color bear a disproportionate burden of preterm birth and intrauterine growth restriction (Bryant et al., 2010, Crawford et al., 2017, National Academies of Sciences Engineering and Medicine, 2020). We also observe poor birth outcomes in women with low socio-economic status (Amjad et al., 2019). Based on the work done on fetal origins of adult disease and the microbiome, it is clear that the circumstances surrounding one’s birth matter a great deal for later health for the individual and her or his children and grandchildren (Cresci and Bawden, 2015, Fernandez-Twinn et al., 2019, Yarde et al., 2013). These inequities at birth reinforce the more generalized health inequities shouldered by communities of color in the United States across generations.
Ideally, midwifery care would be a pillar in any strategy designed to reduce inequities in maternal and child health outcomes (Sandall et al., 2016). However, the U.S. midwifery workforce is not currently extensive enough or sufficiently diverse to offer every pregnant woman a midwife in and from her own community, despite decades of robust evidence indicating such an approach could dramatically improve outcomes (Allen et al., 2016, Cheyney et al., 2015, Homer et al., 2014, National Academies of Sciences Engineering and Medicine, 2020, Sandall et al., 2016). Furthermore, even if we decided tomorrow to quadruple the midwifery workforce (it is, after all, the year of the Nurse and Midwife; World Health Assembly, 2019), training midwives takes several years and our existing nursing and midwifery schools do not currently have the capacity to sufficiently increase their enrollments (Accreditation Commission for Midwifery Education, 2019).
In the meantime, we could offer doulas to all childbearing families. These traditional health workers can be trained in a matter of weeks, and once in practice they provide the health education, social support, and continuity of care midwives are often unable to provide because they are constrained by hospital policies (Dahlen et al., 2011). Excellent maternal and child outcomes have been associated with the use of doulas (Bohren et al., 2017), and depending on the particular state in question, reimbursement of $929–$1,047 (average $986) is cost effective because of the vast reductions in preterm and cesarean births (Kozhimannil et al., 2016).
Universal access to doulas during childbirth could be operationalized in practice in a few different ways. First, hospitals could employ doulas as part of their maternity care teams and include their services for all childbearing women as part of the overall care package. As accountability to quality of care has become more prominent since the Affordable Care Act, most hospital administrators are interested in reducing cesarean rates. Doulas would almost certainly help achieve this goal (Bohren et al., 2017). Doula care is a cost-effective, evidence-based solution—the proverbial magic bullet.
The other way doula care could be made more accessible is by enabling individual doulas or multi-doula practices (call doula “hubs” in some states) to bill insurers for services. In practice, this means state Medicaid programs would need to begin to reimburse for doula care; private insurers would likely follow suit. Oregon is one of the few states that has done this via a state Traditional Health Worker Registry. Doulas who meet the training standards set by the state can apply to be on the Registry, after which they can bill for services. Implementation of this system has not been entirely smooth sailing. However, it now seems to be working in at least some areas of the state, since more families from traditionally underrepresented groups can access doula care without cost to themselves.
It is not yet clear which of these two implementation methods would be more effective in the U.S. healthcare system. Addressing the systemic racism underpinning centuries of poorer health outcomes for minority families should be our nation’s top priority. One way to immediately begin to move the needle on maternal and child health outcomes for communities of color is to provide every childbearing woman who wants one with a socially and linguistically matched doula. As Dr. Christiane Northrup wrote in her iconic book Women’s Bodies, Women’s Wisdom, if doulas were a drug, it would be unethical not to use them (Northrup, 2010).
Acknowledgment
The authors acknowledge Sabrina Pillai, MPH, for assistance with the literature searches for this column.
Biographies
Marit L. Bovbjerg, PhD, MS, is an assistant professor of epidemiology in the College of Public Health and Human Sciences, Oregon State University, Corvallis, OR.
Melissa Cheyney, PhD, LDM, is an associate professor of anthropology in the College of Liberal Arts, Oregon State University, Corvallis, OR.
Footnotes
The authors report no conflict of interest or relevant financial relationships.
References
- Accreditation Commission for Midwifery Education . American College of Nurse-Midwives; 2019. Midwifery education trends report 2019. [Google Scholar]
- Allen J., Kildea S., Stapleton H. How optimal caseload midwifery can modify predictors for preterm birth in young women: Integrated findings from a mixed methods study. Midwifery. 2016;41:30–38. doi: 10.1016/j.midw.2016.07.012. [DOI] [PubMed] [Google Scholar]
- Amjad S., Chandra S., Osornio-Vargas A., Voaklander D., Ospina M.B. Maternal area of residence, socioeconomic status, and risk of adverse maternal and birth outcomes in adolescent mothers. Journal of Obstetrics and Gynaecology Canada. 2019;41(12):1752–1759. doi: 10.1016/j.jogc.2019.02.126. [DOI] [PubMed] [Google Scholar]
- Bohren M.A., Hofmeyr G.J., Sakala C., Fukuzawa R.K., Cuthbert A. Continuous support for women during childbirth. Cochrane Database of Systematic Reviews, 2017. 2017;(7):CD003766. doi: 10.1002/14651858.CD003766.pub6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bryant A.S., Worjoloh A., Caughey A.B., Washington A.E. Racial/ethnic disparities in obstetric outcomes and care: Prevalence and determinants. American Journal of Obstetrics and Gynecology. 2010;202(4):335–343. doi: 10.1016/j.ajog.2009.10.864. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheyney M., Olsen C., Bovbjerg M., Everson C., Darragh I., Potter B. Practitioner and practice characteristics of certified professional midwives in the United States: Results of the 2011 North American registry of midwives survey. Journal of Midwifery & Women’s Health. 2015;60(5):534–545. doi: 10.1111/jmwh.12367. [DOI] [PubMed] [Google Scholar]
- Crawford S., Joshi N., Boulet S.L., Bailey M.A., Hood M.-E., Manning S.E.…States Monitoring Assisted Reproductive Technology (SMART) Collaborative Maternal racial and ethnic disparities in neonatal birth outcomes with and without assisted reproduction. Obstetrics & Gynecology. 2017;129(6):1022–1030. doi: 10.1097/AOG.0000000000002031. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cresci G.A., Bawden E. Gut microbiome: What we do and don’t know. Nutrition in Clinical Practice. 2015;30(6):734–746. doi: 10.1177/0884533615609899. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dahlen H.G., Jackson M., Stevens J. Homebirth, freebirth and doulas: Casualty and consequences of a broken maternity system. Women and Birth. 2011;24(1):47–50. doi: 10.1016/j.wombi.2010.11.002. [DOI] [PubMed] [Google Scholar]
- Fernandez-Twinn D.S., Hjort L., Novakovic B., Ozanne S.E., Saffery R. Intrauterine programming of obesity and type 2 diabetes. Diabetologia. 2019;62(10):1789–1801. doi: 10.1007/s00125-019-4951-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Homer C.S.E., Friberg I.K., Dias M.A.B., ten Hoope-Bender P., Sandall J., Speciale A.M., Bartlett L.A. The projected effect of scaling up midwifery. Lancet. 2014;384(9948):1146–1157. doi: 10.1016/S0140-6736(14)60790-X. [DOI] [PubMed] [Google Scholar]
- Hoyert D.L., Minino A.M. Maternal mortality in the United States: Changes in coding, publication, and data release, 2018. National Vital Statistics Reports. 2020;69(2):1–18. https://www.cdc.gov/nchs/data/nvsr/nvsr69/nvsr69_02-508.pdf [PubMed] [Google Scholar]
- Kozhimannil K.B., Hardeman R.R., Alarid-Escudero F., Vogelsang C.A., Blauer-Peterson C., Howell E.A. Modeling the cost-effectiveness of doula care associated with reductions in preterm birth and cesarean delivery. Birth. 2016;43(1):20–27. doi: 10.1111/birt.12218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MacDorman M.F., Declercq E., Cabral H., Morton C. Recent increases in the U.S. maternal mortality rate: Disentangling trends from measurement issues. Obstetrics & Gynecology. 2016;128(3):447–455. doi: 10.1097/AOG.0000000000001556. [DOI] [PMC free article] [PubMed] [Google Scholar]
- National Academies of Sciences, Engineering, and Medicine Birth settings in America: Outcomes, quality, access, and choice. 2020. [DOI]
- Northrup C. 3rd ed. Hay House Inc; 2010. Women’s bodies, women’s wisdom. [Google Scholar]
- Sandall J., Soltani H., Gates S., Shennan A., Devane D. Midwife-led continuity models versus other models of care for childbearing women. Cochrane Database of Systematic Reviews, 2016. 2016;(4):CD004667. doi: 10.1002/14651858.CD004667.pub5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- World Health Assembly 2020: International Year of the Nurse and the Midwife (A72/54. 2019. https://apps.who.int/gb/ebwha/pdf_files/WHA72/A72_54Rev1-en.pdf
- Yarde F., Broekmans F.J.M., van der Pal-de Bruin K.M., Schönbeck Y., te Velde E.R., Stein A.D., Lumey L.H. Prenatal famine, birthweight, reproductive performance and age at menopause: The Dutch Hunger Winter Families Study. Human Reproduction. 2013;28(12):3328–3336. doi: 10.1093/humrep/det331. [DOI] [PMC free article] [PubMed] [Google Scholar]
References
From Cochrane Database of Systematic Reviews (CDSR) Issues 03–04 (2020)
Systematic Reviews in CDSR: Women’s Health
-
•
Ovarian suppression for adjuvant treatment of hormone receptor-positive early breast cancer
-
•
Health education interventions to promote early presentation and referral for women with symptoms of endometrial cancer
-
•
Green tea (Camellia sinensis) for the prevention of cancer
Systematic Reviews in CDSR: Fertility, Contraception, and ART
-
•
Self-administered versus provider-administered medical abortion
-
•
Intra-uterine insemination for unexplained subfertility
Systematic Reviews in CDSR: Pregnancy and Birth
-
•
Death audits and reviews for reducing maternal, perinatal and child mortality
-
•
Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections
Systematic Reviews in CDSR: Infant Health and Breastfeeding
-
•
Zinc supplementation for the promotion of growth and prevention of infections in infants less than six months of age
-
•
Early versus late parenteral nutrition for critically ill term and late preterm infants
-
•
Non-invasive respiratory support for the management of transient tachypnea of the newborn
-
•
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants
-
•
Diaphragm-triggered non-invasive respiratory support in preterm infants
-
•
Normal saline (0.9% sodium chloride) versus heparin intermittent flushing for the prevention of occlusion in long-term central venous catheters in infants and children
-
•
Postnatal corticosteroids for transient tachypnoea of the newborn
Systematic Reviews in CDSR: Nursing Education and Practice
-
•
Health workers’ perceptions and experiences of using mHealth technologies to deliver primary healthcare services: A qualitative evidence synthesis
Systematic Reviews in CDSR: SARS-CoV-2
-
•
Quarantine alone or in combination with other public health measures to control COVID-19: A rapid review
-
•
Hand cleaning with ash for reducing the spread of viral and bacterial infections: A rapid review
-
•
Personal protective equipment for preventing highly infectious diseases due to exposure to contaminated body fluids in healthcare staff
Evidence-Based Reviews From Other Sources
Recent Evidence-Based Reviews: Women’s Health
- Abdin S., Lavallée J.F., Faulkner J., Husted M. A systematic review of the effectiveness of physical activity interventions in adults with breast cancer by physical activity type and mode of participation. Psycho-Oncology. 2019;28(7):1381–1393. doi: 10.1002/pon.5101. [DOI] [PubMed] [Google Scholar]
- Ambikairajah A., Walsh E., Tabatabaei-Jafari H., Cherbuin N. Fat mass changes during menopause: A metaanalysis. American Journal of Obstetrics and Gynecology. 2019;221(5):393–409.e50. doi: 10.1016/j.ajog.2019.04.023. [DOI] [PubMed] [Google Scholar]
- Armour M., Parry K., Al-Dabbas M.A., Curry C., Holmes K., MacMillan F.…Smith C.A. Self-care strategies and sources of knowledge on menstruation in 12,526 young women with dysmenorrhea: A systematic review and meta-analysis. PLOS ONE. 2019;14(7) doi: 10.1371/journal.pone.0220103. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradley L.D., Pasic R.P., Miller L.E. Clinical performance of radiofrequency ablation for treatment of uterine fibroids: Systematic review and meta-analysis of prospective studies. Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. 2019;29(12):1507–1517. doi: 10.1089/lap.2019.0550. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carr T.L., Groot G., Cochran D., Holtslander L. Patient information needs and breast reconstruction after mastectomy: A qualitative meta-synthesis. Cancer Nursing. 2019;42(3):229–241. doi: 10.1097/NCC.0000000000000599. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carroquino-Garcia P., Jiménez-Rejano J.J., Medrano-Sanchez E., de la Casa-Almeida M., Diaz-Mohedo E., Suarez-Serrano C. Therapeutic exercise in the treatment of primary dysmenorrhea: A systematic review and meta-analysis. Physical Therapy. 2019;99(10):1371–1380. doi: 10.1093/ptj/pzz101. [DOI] [PubMed] [Google Scholar]
- Constantine G.D., Graham S., Lapane K., Ohleth K., Bernick B., Liu J., Mirkin S. Endometrial safety of low-dose vaginal estrogens in menopausal women: A systematic evidence review. Menopause. 2019;26(7):800–807. doi: 10.1097/GME.0000000000001315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coughlin S.S. Social determinants of breast cancer risk, stage, and survival. Breast Cancer Research and Treatment. 2019;177(3):537–548. doi: 10.1007/s10549-019-05340-7. [DOI] [PubMed] [Google Scholar]
- Coughlin S.S., Caplan L.S., Williams V. Home-based physical activity interventions for breast cancer patients receiving primary therapy: A systematic review. Breast Cancer Research and Treatment. 2019;178(3):513–522. doi: 10.1007/s10549-019-05424-4. [DOI] [PubMed] [Google Scholar]
- Gray T.G., Vickers H., Jha S., Jones G.L., Brown S.R., Radley S.C. A systematic review of non-invasive modalities used to identify women with anal incontinence symptoms after childbirth. International Urogynecology Journal. 2019;30(6):869–879. doi: 10.1007/s00192-018-3819-8. [DOI] [PubMed] [Google Scholar]
- Jouybari L., Kiani F., Akbari A., Sanagoo A., Sayehmiri F., Aaseth J.…Bjørklund G. A meta-analysis of zinc levels in breast cancer. Journal of Trace Elements in Medicine and Biology. 2019;56:90–99. doi: 10.1016/j.jtemb.2019.06.017. [DOI] [PubMed] [Google Scholar]
- Khushalani J.S., Trogdon J.G., Ekwueme D.U., Yabroff K.R. Economics of public health programs for underserved populations: A review of economic analysis of the National Breast and Cervical Cancer Early Detection Program. Cancer Causes & Control. 2019;30(12):1351–1363. doi: 10.1007/s10552-019-01235-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krassuski L., Vennedey V., Stock S., Kautz-Freimuth S. Effectiveness of decision aids for female BRCA1 and BRCA2 mutation carriers: A systematic review. BioMed Central Medical Informatics and Decision Making. 2019;19(1):154. doi: 10.1186/s12911-019-0872-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kumar S., Long J., Kehoe S., Sundar S., Cummins C. Quality of life outcomes following surgery for advanced ovarian cancer: A systematic review and meta-analysis. International Journal of Gynecological Cancer. 2019;29(8):1285–1291. doi: 10.1136/ijgc-2018-000125. [DOI] [PubMed] [Google Scholar]
- Lee I., Cooney L.G., Saini S., Sammel M.D., Allison K.C., Dokras A. Increased odds of disordered eating in polycystic ovary syndrome: A systematic review and meta-analysis. Eating and Weight Disorders. 2019;24(5):787–797. doi: 10.1007/s40519-018-0533-y. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leonardi M., Hicks C., El-Assaad F., El-Omar E., Condous G. Endometriosis and the microbiome: A systematic review. British Journal of Obstetrics and Gynaecology. 2020;127(2):239–249. doi: 10.1111/1471-0528.15916. [DOI] [PubMed] [Google Scholar]
- Li C., Fan H., Xiang Q., Xu L., Zhang Z., Liu Q.…Cui Y. Prognostic value of receptor status conversion following neoadjuvant chemotherapy in breast cancer patients: A systematic review and meta-analysis. Breast Cancer Research and Treatment. 2019;178(3):497–504. doi: 10.1007/s10549-019-05421-7. [DOI] [PubMed] [Google Scholar]
- Li M., Hung A., Lenon G.B., Yang A.W.H. Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis. PLOS ONE. 2019;14(9) doi: 10.1371/journal.pone.0222383. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Li X.T., Li P.Y., Liu Y., Yang H.S., He L.Y., Fang Y.G.…Chaplin J.E. Health-related quality-of-life among patients with premature ovarian insufficiency: A systematic review and meta-analysis. Quality of Life Research. 2020;29(1):19–36. doi: 10.1007/s11136-019-02326-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Long H., Brooks J.M., Harvie M., Maxwell A., French D.P. How do women experience a false-positive test result from breast screening? A systematic review and thematic synthesis of qualitative studies. British Journal of Cancer. 2019;121(4):351–358. doi: 10.1038/s41416-019-0524-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Louro J., Posso M., Hilton Boon M., Román M., Domingo L., Castells X., Sala M. A systematic review and quality assessment of individualised breast cancer risk prediction models. British Journal of Cancer. 2019;121(1):76–85. doi: 10.1038/s41416-019-0476-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LoVette A., Kuo C., Harrison A. Strength-based interventions for HIV prevention and sexual risk reduction among girls and young women: A resilience-focused systematic review. Global Public Health. 2019;14(10):1454–1478. doi: 10.1080/17441692.2019.1602157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Magno L., da Silva L.A.V., Veras M.A., Pereira-Santos M., Dourado I. Stigma and discrimination related to gender identity and vulnerability to HIV/AIDS among transgender women: A systematic review. Cadernos De Saude Publica. 2019;35(4) doi: 10.1590/0102-311X00112718. [DOI] [PubMed] [Google Scholar]
- Mudhune G.H., Armour M., McBride K.A. Safety of menopausal hormone therapy in breast cancer survivors older than fifty at diagnosis: A systematic review and meta-analysis. Breast. 2019;47:43–55. doi: 10.1016/j.breast.2019.06.002. [DOI] [PubMed] [Google Scholar]
- Murfin J., Irvine F., Meechan-Rogers R., Swift A. Education, income and occupation and their influence on the uptake of cervical cancer prevention strategies: A systematic review. Journal of Clinical Nursing. 2020;29(3–4):393–415. doi: 10.1111/jocn.15094. [DOI] [PubMed] [Google Scholar]
- Norenhag J., Du J., Olovsson M., Verstraelen H., Engstrand L., Brusselaers N. The vaginal microbiota, human papillomavirus and cervical dysplasia: A systematic review and network meta-analysis. British Journal of Obstetrics and Gynaecology. 2020;127(2):171–180. doi: 10.1111/1471-0528.15854. [DOI] [PubMed] [Google Scholar]
- Ortiz R.R., Smith A., Coyne-Beasley T. A systematic literature review to examine the potential for social media to impact HPV vaccine uptake and awareness, knowledge, and attitudes about HPV and HPV vaccination. Human Vaccines & Immunotherapeutics. 2019;15(7–8):1465–1475. doi: 10.1080/21645515.2019.1581543. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raffone A., Travaglino A., Saccone G., Alviggi C., Mascolo M., De Placido G.…Zullo F. Management of women with atypical polypoid adenomyoma of the uterus: A quantitative systematic review. Acta Obstetricia Et Gynecologica Scandinavica. 2019;98(7):842–855. doi: 10.1111/aogs.13553. [DOI] [PubMed] [Google Scholar]
- Raffone A., Travaglino A., Saccone G., Insabato L., Mollo A., De Placido G., Zullo F. Endometrial hyperplasia and progression to cancer: Which classification system stratifies the risk better? A systematic review and meta-analysis. Archives of Gynecology and Obstetrics. 2019;299(5):1233–1242. doi: 10.1007/s00404-019-05103-1. [DOI] [PubMed] [Google Scholar]
- Ren Z.-J., Cao D.-H., Zhang Q., Ren P.-W., Liu L.-R., Wei Q.…Dong Q. First-degree family history of breast cancer is associated with prostate cancer risk: A systematic review and meta-analysis. BioMed Central Cancer. 2019;19(1):871. doi: 10.1186/s12885-019-6055-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ribeiro I.L., Moreira R.F.C., Ferrari A.V., Alburquerque-Sendín F., Camargo P.R., Salvini T.F. Effectiveness of early rehabilitation on range of motion, muscle strength and arm function after breast cancer surgery: A systematic review of randomized controlled trials. Clinical Rehabilitation. 2019;33(12):1876–1886. doi: 10.1177/0269215519873026. [DOI] [PubMed] [Google Scholar]
- Riemma G., Schiattarella A., La Verde M., Zarobbi G., Garzon S., Cucinella G.…De Franciscis P. Efficacy of low-dose paroxetine for the treatment of hot flushes in surgical and physiological postmenopausal women: Systematic review and meta-analysis of randomized trials. Medicina. 2019;55(9):554. doi: 10.3390/medicina55090554. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roman Lay A.A., do Nascimento C.F., Horta B.L., Dias Porto Chiavegatto Filho A. Reproductive factors and age at natural menopause: A systematic review and meta-analysis. Maturitas. 2020;131:57–64. doi: 10.1016/j.maturitas.2019.10.012. [DOI] [PubMed] [Google Scholar]
- Ryan N.a.J., Glaire M.A., Blake D., Cabrera-Dandy M., Evans D.G., Crosbie E.J. The proportion of endometrial cancers associated with Lynch syndrome: A systematic review of the literature and meta-analysis. Genetics in Medicine. 2019;21(10):2167–2180. doi: 10.1038/s41436-019-0536-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saibudeen A., Makris G.C., Elzein A., Wigham A., Patel R., Husainy M.A.…Uberoi R. Pain management protocols during uterine fibroid embolisation: A Systematic review of the evidence. Cardiovascular and Interventional Radiology. 2019;42(12):1663–1677. doi: 10.1007/s00270-019-02327-1. [DOI] [PubMed] [Google Scholar]
- Vromans R., Tenfelde K., Pauws S., van Eenbergen M., Mares-Engelberts I., Velikova G.…Krahmer E. Assessing the quality and communicative aspects of patient decision aids for early-stage breast cancer treatment: A systematic review. Breast Cancer Research and Treatment. 2019;178(1):1–15. doi: 10.1007/s10549-019-05351-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wang Yizi, Ren F., Song Z., Chen P., Liu S., Ouyang L. Statin use and the risk of ovarian and endometrial cancers: A meta-analysis. BioMed Central Cancer. 2019;19(1):730. doi: 10.1186/s12885-019-5954-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheeler L.J., Desanto K., Teal S.B., Sheeder J., Guntupalli S.R. Intrauterine device use and ovarian cancer risk: A systematic review and meta-analysis. Obstetrics & Gynecology. 2019;134(4):791–800. doi: 10.1097/AOG.0000000000003463. [DOI] [PubMed] [Google Scholar]
- Williams P., Murchie P., Cruickshank M.E., Bond C.M., Burton C.D. The use, quality and effectiveness of pelvic examination in primary care for the detection of gynaecological cancer: A systematic review. Family Practice. 2019;36(4):378–386. doi: 10.1093/fampra/cmy092. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woopen H., Richter R., Chekerov R., Inci G., Alavi S., Grabowski J.P., Sehouli J. Prognostic role of chemotherapy-induced nausea and vomiting in recurrent ovarian cancer patients: Results of an individual participant data meta-analysis in 1213. Supportive Care in Cancer. 2020;28(1):73–78. doi: 10.1007/s00520-019-04778-1. [DOI] [PubMed] [Google Scholar]
- Wright J.D., Matsuo K., Huang Y., Tergas A.I., Hou J.Y., Khoury-Collado F.…Hershman D.L. Prognostic performance of the 2018 International Federation of Gynecology and Obstetrics cervical cancer staging guidelines. Obstetrics & Gynecology. 2019;134(1):49–57. doi: 10.1097/AOG.0000000000003311. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wu Z.-H., Tang Y., Niu X., Pu F.-F., Xiao X.-Y., Kong W. Prostatic-specific antigen (PSA) levels in patients with polycystic ovary syndrome (PCOS): A meta-analysis. Journal of Ovarian Research. 2019;12(1):94. doi: 10.1186/s13048-019-0569-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yang L., Chen H. Establishing the prognostic value of platelet-to-lymphocyte ratio in cervical cancer: A systematic review and meta-analysis. International Journal of Gynecological Cancer. 2019;29(4):683–690. doi: 10.1136/ijgc-2018-000090. [DOI] [PubMed] [Google Scholar]
- Zwolsman S., Kastelein A., Daams J., Roovers J.-P., Opmeer B.C., WOMEN-UP Consortium Heterogeneity of cost estimates in health economic evaluation research. A systematic review of stress urinary incontinence studies. International Urogynecology Journal. 2019;30(7):1045–1059. doi: 10.1007/s00192-018-3814-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
Recent Evidence-Based Reviews: Fertility, Contraception, and ART
- Alves D.S., Times V.C., da Silva É.M.A., Melo P.S.A., Novaes M. de A. Advances in obstetric telemonitoring: A systematic review. International Journal of Medical Informatics. 2020;134:104004. doi: 10.1016/j.ijmedinf.2019.104004. [DOI] [PubMed] [Google Scholar]
- Corkum K.S., Rhee D.S., Wafford Q.E., Demeestere I., Dasgupta R., Baertschiger R.…Lautz T.B. Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review. Journal of Pediatric Surgery. 2019;54(11):2200–2209. doi: 10.1016/j.jpedsurg.2018.12.021. [DOI] [PubMed] [Google Scholar]
- Moreno-Sepulveda J., Checa M.A. Risk of adverse perinatal outcomes after oocyte donation: A systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2019;36(10):2017–2037. doi: 10.1007/s10815-019-01552-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simopoulou M., Sfakianoudis K., Maziotis E., Tsioulou P., Giannelou P., Grigoriadis S.…Koutsilieris M. Investigating the optimal time for intrauterine human chorionic gonadotropin infusion in order to improve IVF outcome: A systematic review and meta-analysis. In Vivo. 2019;33(6):1737–1749. doi: 10.21873/invivo.11664. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vargas S.E., Midoun M.M., Guillen M., Getz M.L., Underhill K., Kuo C., Guthrie K.M., other members of the Project WISH Research Team A qualitative systematic review of women’s experiences using contraceptive vaginal rings: Implications for new technologies. Perspectives on Sexual and Reproductive Health. 2019;51(2):71–80. doi: 10.1363/psrh.12103. [DOI] [PMC free article] [PubMed] [Google Scholar]
Recent Evidence-Based Reviews: Pregnancy and Birth
- Amiel Castro R.T., Pataky E.A., Ehlert U. Associations between premenstrual syndrome and postpartum depression: A systematic literature review. Biological Psychology. 2019;147:107612. doi: 10.1016/j.biopsycho.2018.10.014. [DOI] [PubMed] [Google Scholar]
- Anton O., Jordan H., Rabe H. Strategies for implementing placental transfusion at birth: A systematic review. Birth. 2019;46(3):411–427. doi: 10.1111/birt.12398. [DOI] [PubMed] [Google Scholar]
- Arafa A., Dong J.-Y. Depression and risk of gestational diabetes: A meta-analysis of cohort studies. Diabetes Research and Clinical Practice. 2019;156:107826. doi: 10.1016/j.diabres.2019.107826. [DOI] [PubMed] [Google Scholar]
- Cai C., Vandermeer B., Khurana R., Nerenberg K., Featherstone R., Sebastianski M., Davenport M.H. The impact of occupational shift work and working hours during pregnancy on health outcomes: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2019;221(6):563–576. doi: 10.1016/j.ajog.2019.06.051. [DOI] [PubMed] [Google Scholar]
- Chamberlain C., Ralph N., Hokke S., Clark Y., Gee G., Stansfield C.…Healing The Past By Nurturing The Future group Healing the past by nurturing the future: A qualitative systematic review and meta-synthesis of pregnancy, birth and early postpartum experiences and views of parents with a history of childhood maltreatment. PLOS ONE. 2019;14(12) doi: 10.1371/journal.pone.0225441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chun H., Leung C., Wen S.W., McDonald J., Shin H.H. Maternal exposure to air pollution and risk of autism in children: A systematic review and meta-analysis. Environmental Pollution. 2020;256:113307. doi: 10.1016/j.envpol.2019.113307. [DOI] [PubMed] [Google Scholar]
- Cuningham W., Geard N., Fielding J.E., Braat S., Madhi S.A., Nunes M.C.…Moss R. Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis. Influenza and Other Respiratory Viruses. 2019;13(5):438–452. doi: 10.1111/irv.12649. [DOI] [PMC free article] [PubMed] [Google Scholar]
- D’Ambrosio V., Vena F., Di Mascio D., Faralli I., Musacchio L., Boccherini C.…Giancotti A. Obstetrical outcomes in women with history of breast cancer: A systematic review and meta-analysis. Breast Cancer Research and Treatment. 2019;178(3):485–492. doi: 10.1007/s10549-019-05408-4. [DOI] [PubMed] [Google Scholar]
- Dathe K., Hultzsch S., Pritchard L.W., Schaefer C. Risk estimation of fetal adverse effects after short-term second trimester exposure to non-steroidal anti-inflammatory drugs: A literature review. European Journal of Clinical Pharmacology. 2019;75(10):1347–1353. doi: 10.1007/s00228-019-02712-2. [DOI] [PubMed] [Google Scholar]
- Davidoff C.L., Lo Presti A., Rogers J.M., Simons M., Assaad N.N.A., Stoodley M.A., Morgan M.K. Risk of first hemorrhage of brain arteriovenous malformations during pregnancy: A systematic review of the literature. Neurosurgery. 2019;85(5):E806–E814. doi: 10.1093/neuros/nyz175. [DOI] [PubMed] [Google Scholar]
- Dennison R.A., Ward R.J., Griffin S.J., Usher-Smith J.A. Women’s views on lifestyle changes to reduce the risk of developing type 2 diabetes after gestational diabetes: A systematic review, qualitative synthesis and recommendations for practice. Diabetic Medicine. 2019;36(6):702–717. doi: 10.1111/dme.13926. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Di Mascio D., Acharya G., Khalil A., Odibo A., Prefumo F., Liberati M.…D’Antonio F. Birthweight discordance and neonatal morbidity in twin pregnancies: A systematic review and meta-analysis. Acta Obstetricia Et Gynecologica Scandinavica. 2019;98(10):1245–1257. doi: 10.1111/aogs.13613. [DOI] [PubMed] [Google Scholar]
- Di Mascio D., Buca D., Khalil A., Rizzo G., Makatsariya A., Sileo F., D’Antonio F. Outcome of isolated fetal talipes: A systematic review and meta-analysis. Acta Obstetricia Et Gynecologica Scandinavica. 2019;98(11):1367–1377. doi: 10.1111/aogs.13637. [DOI] [PubMed] [Google Scholar]
- Du M.-C., Ouyang Y.-Q., Nie X.-F., Huang Y., Redding S.R. Effects of physical exercise during pregnancy on maternal and infant outcomes in overweight and obese pregnant women: A meta-analysis. Birth. 2019;46(2):211–221. doi: 10.1111/birt.12396. [DOI] [PubMed] [Google Scholar]
- Evans K., Spiby H., Morrell J.C. Non-pharmacological interventions to reduce the symptoms of mild to moderate anxiety in pregnant women. A systematic review and narrative synthesis of women’s views on the acceptability of and satisfaction with interventions. Archives of Women’s Mental Health. 2020;23(1):11–28. doi: 10.1007/s00737-018-0936-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ferreira R.D. da S., Negrini R., Bernardo W.M., Simões R., Piato S. The effects of sildenafil in maternal and fetal outcomes in pregnancy: A systematic review and meta-analysis. PLOS ONE. 2019;14(7) doi: 10.1371/journal.pone.0219732. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
- Flannery C., Fredrix M., Olander E.K., McAuliffe F.M., Byrne M., Kearney P.M. Effectiveness of physical activity interventions for overweight and obesity during pregnancy: A systematic review of the content of behaviour change interventions. International Journal of Behavioral Nutrition and Physical Activity. 2019;16(1):97. doi: 10.1186/s12966-019-0859-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gaucher L., Occelli P., Deneux-Tharaux C., Colin C., Gaucherand P., Touzet S., Dupont C. Non-clinical interventions to prevent postpartum haemorrhage and improve its management: A systematic review. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;240:300–309. doi: 10.1016/j.ejogrb.2019.07.018. [DOI] [PubMed] [Google Scholar]
- Georgiadou D., Afink G.B., van Dijk M. The apelinergic-axis in human preeclamptic pregnancies: A systematic review. Pregnancy Hypertension. 2019;17:148–157. doi: 10.1016/j.preghy.2019.06.002. [DOI] [PubMed] [Google Scholar]
- González-Mesa E., Cuenca-Marín C., Suarez-Arana M., Tripiana-Serrano B., Ibrahim-Díez N., Gonzalez-Cazorla A., Blasco-Alonso M. Poor sleep quality is associated with perinatal depression. A systematic review of last decade scientific literature and meta-analysis. Journal of Perinatal Medicine. 2019;47(7):689–703. doi: 10.1515/jpm-2019-0214. [DOI] [PubMed] [Google Scholar]
- Goto E. Effectiveness of prenatal lipid-based nutrient supplementation to improve birth outcomes: A meta-analysis. American Journal of Tropical Medicine and Hygiene. 2019;101(5):994–999. doi: 10.4269/ajtmh.19-0287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grenvik J.M., Rosenthal E., Saccone G., Della Corte L., Quist-Nelson J., Gerkin R.D.…Berghella V. Peanut ball for decreasing length of labor: A systematic review and meta-analysis of randomized controlled trials. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;242:159–165. doi: 10.1016/j.ejogrb.2019.09.018. [DOI] [PubMed] [Google Scholar]
- Grigoriadis S., Graves L., Peer M., Mamisashvili L., Tomlinson G., Vigod S.N.…Richter M. A systematic review and meta-analysis of the effects of antenatal anxiety on postpartum outcomes. Archives of Women’s Mental Health. 2019;22(5):543–556. doi: 10.1007/s00737-018-0930-2. [DOI] [PubMed] [Google Scholar]
- Guo B.-Q., Li H.-B., Zhai D.-S., Ding S.-B. Association of maternal prenatal folic acid intake with subsequent risk of autism spectrum disorder in children: A systematic review and meta-analysis. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2019;94:109650. doi: 10.1016/j.pnpbp.2019.109650. [DOI] [PubMed] [Google Scholar]
- Gyorkos T.W., St-Denis K. Systematic review of exposure to albendazole or mebendazole during pregnancy and effects on maternal and child outcomes, with particular reference to exposure in the first trimester. International Journal for Parasitology. 2019;49(7):541–554. doi: 10.1016/j.ijpara.2019.02.005. [DOI] [PubMed] [Google Scholar]
- Hastie R., Brownfoot F.C., Cluver C.A., Walker S.P., Hesselman S., Tong S., Bergman L. Predictive value of the signs and symptoms preceding eclampsia: A systematic review. Obstetrics & Gynecology. 2019;134(4):677–684. doi: 10.1097/AOG.0000000000003476. [DOI] [PubMed] [Google Scholar]
- Janbek J., Specht I.O., Heitmann B.L. Associations between vitamin D status in pregnancy and offspring neurodevelopment: A systematic literature review. Nutrition Reviews. 2019;77(5):330–349. doi: 10.1093/nutrit/nuy071. [DOI] [PubMed] [Google Scholar]
- Jansen C.H.J.R., Kleinrouweler C.E., van Leeuwen L., Ruiter L., Limpens J., van Wely M.…Pajkrt E. Final outcome of a second trimester low-positioned placenta: A systematic review and meta-analysis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;240:197–204. doi: 10.1016/j.ejogrb.2019.06.020. [DOI] [PubMed] [Google Scholar]
- Jauniaux E., Bunce C., Grønbeck L., Langhoff-Roos J. Prevalence and main outcomes of placenta accreta spectrum: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2019;221(3):208–218. doi: 10.1016/j.ajog.2019.01.233. [DOI] [PubMed] [Google Scholar]
- Jeong S., Jang E.J., Jo J., Jang S. Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis. PLOS ONE. 2019;14(8) doi: 10.1371/journal.pone.0220910. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones K., Webb S., Manresa M., Hodgetts-Morton V., Morris R.K. The incidence of wound infection and dehiscence following childbirth-related perineal trauma: A systematic review of the evidence. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;240:1–8. doi: 10.1016/j.ejogrb.2019.05.038. [DOI] [PubMed] [Google Scholar]
- Kanninen T.T., Quist-Nelson J., Sisti G., Berghella V. Chlamydia trachomatis screening in preterm labor: A systematic review and meta-analysis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;240:242–247. doi: 10.1016/j.ejogrb.2019.06.032. [DOI] [PubMed] [Google Scholar]
- Kataria Y., Gaewsky L., Ellervik C. Prenatal smoking exposure and cardio-metabolic risk factors in adulthood: A general population study and a meta-analysis. International Journal of Obesity. 2019;43(4):763–773. doi: 10.1038/s41366-018-0206-y. [DOI] [PubMed] [Google Scholar]
- Kołomańska-Bogucka D., Mazur-Bialy A.I. Physical activity and the occurrence of postnatal depression-a systematic review. Medicina. 2019;55(9) doi: 10.3390/medicina55090560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lara-Cinisomo S., Wood J., Fujimoto E.M. A systematic review of cultural orientation and perinatal depression in Latina women: Are acculturation, Marianismo, and religiosity risks or protective factors? Archives of Women’s Mental Health. 2019;22(5):557–567. doi: 10.1007/s00737-018-0920-4. [DOI] [PubMed] [Google Scholar]
- Li H., Bowen A., Bowen R., Balbuena L., Feng C., Bally J., Muhajarine N. Mood instability during pregnancy and postpartum: A systematic review. Archives of Women’s Mental Health. 2020;23(1):29–41. doi: 10.1007/s00737-019-00956-6. [DOI] [PubMed] [Google Scholar]
- Liu N., Gou W.-H., Wang J., Chen D.-D., Sun W.-J., Guo P.-P.…Zhang W. Effects of exercise on pregnant women’s quality of life: A systematic review. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;242:170–177. doi: 10.1016/j.ejogrb.2019.03.009. [DOI] [PubMed] [Google Scholar]
- Liu X., Wang Y., Zhang F., Zhong X., Ou R., Luo X., Qi H. Double- versus single-balloon catheters for labour induction and cervical ripening: A meta-analysis. BioMed Central Pregnancy and Childbirth. 2019;19(1):358. doi: 10.1186/s12884-019-2491-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lou S., Hvidman L., Uldbjerg N., Neumann L., Jensen T.F., Haben J.-G., Carstensen K. Women’s experiences of postterm induction of labor: A systematic review of qualitative studies. Birth. 2019;46(3):400–410. doi: 10.1111/birt.12412. [DOI] [PubMed] [Google Scholar]
- Lucas G., Olander E.K., Ayers S., Salmon D. No straight lines—young women’s perceptions of their mental health and wellbeing during and after pregnancy: A systematic review and meta-ethnography. BioMed Central Women’s Health. 2019;19(1):152. doi: 10.1186/s12905-019-0848-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Magoga G., Saccone G., Al-Kouatly H.B., Dahlen G H., Thornton C., Akbarzadeh M.…Berghella V. Warm perineal compresses during the second stage of labor for reducing perineal trauma: A meta-analysis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;240:93–98. doi: 10.1016/j.ejogrb.2019.06.011. [DOI] [PubMed] [Google Scholar]
- Manresa M., Pereda A., Bataller E., Terre-Rull C., Ismail K.M., Webb S.S. Incidence of perineal pain and dyspareunia following spontaneous vaginal birth: A systematic review and meta-analysis. International Urogynecology Journal. 2019;30(6):853–868. doi: 10.1007/s00192-019-03894-0. [DOI] [PubMed] [Google Scholar]
- Manzari N., Matvienko-Sikar K., Baldoni F., O’Keeffe G.W., Khashan A.S. Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: A systematic review and meta-analysis. Social Psychiatry and Psychiatric Epidemiology. 2019;54(11):1299–1309. doi: 10.1007/s00127-019-01745-3. [DOI] [PubMed] [Google Scholar]
- Meier K., Parrish J., D’Souza R. Prediction models for determining the success of labor induction: A systematic review. Acta Obstetricia Et Gynecologica Scandinavica. 2019;98(9):1100–1112. doi: 10.1111/aogs.13589. [DOI] [PubMed] [Google Scholar]
- Moreta D., Vo S., Eslick G.D., Benzie R. Re-evaluating the role of cerebroplacental ratio in predicting adverse perinatal outcome. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2019;242:17–28. doi: 10.1016/j.ejogrb.2019.06.033. [DOI] [PubMed] [Google Scholar]
- Nithiyanantham S.F., Badawi A. Maternal infection with Zika virus and prevalence of congenital disorders in infants: Systematic review and meta-analysis. Canadian Journal of Public Health. 2019;110(5):638–648. doi: 10.17269/s41997-019-00215-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nourollahpour Shiadeh M., Riahi S.M., Khani S., Alizadeh S., Hosseinzadeh R., Hasanpour A.H.…Rostami A. Human immunodeficiency virus and risk of pre-eclampsia and eclampsia in pregnant women: A meta-analysis on cohort studies. Pregnancy Hypertension. 2019;17:269–275. doi: 10.1016/j.preghy.2019.07.008. [DOI] [PubMed] [Google Scholar]
- Oni H.T., Khan M.N., Abdel-Latif M., Buultjens M., Islam M.M. Short-term health outcomes of newborn infants of substance-using mothers in Australia and New Zealand: A systematic review. Journal of Obstetrics and Gynaecology Research. 2019;45(9):1783–1795. doi: 10.1111/jog.14051. [DOI] [PubMed] [Google Scholar]
- Onwochei D.N., Van Ross J., Singh P.M., Salter A., Monks D.T. Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: A systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. International Journal of Obstetric Anesthesia. 2019;40:14–23. doi: 10.1016/j.ijoa.2019.06.007. [DOI] [PubMed] [Google Scholar]
- Pérez-López F.R., Chedraui P., Pérez-Roncero G.R., Martínez-Domínguez S.J., Health Outcomes and Systematic Analyses (HOUSSAY) Project Effectiveness of the cervical pessary for the prevention of preterm birth in singleton pregnancies with a short cervix: A meta-analysis of randomized trials. Archives of Gynecology and Obstetrics. 2019;299(5):1215–1231. doi: 10.1007/s00404-019-05096-x. [DOI] [PubMed] [Google Scholar]
- Pergialiotis V., Bellos I., Hatziagelaki E., Antsaklis A., Loutradis D., Daskalakis G. Progestogens for the prevention of preterm birth and risk of developing gestational diabetes mellitus: A meta-analysis. American Journal of Obstetrics and Gynecology. 2019;221(5):429–436.e5. doi: 10.1016/j.ajog.2019.05.033. [DOI] [PubMed] [Google Scholar]
- Premkumar A., Dude A.M., Haddad L.B., Yee L.M. Combined antiretroviral therapy for HIV and the risk of hypertensive disorders of pregnancy: A systematic review. Pregnancy Hypertension. 2019;17:178–190. doi: 10.1016/j.preghy.2019.05.015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Qassim A., Grivell R.M., Henry A., Kidson-Gerber G., Shand A., Grzeskowiak L.E. Intravenous or oral iron for treating iron deficiency anaemia during pregnancy: Systematic review and meta-analysis. Medical Journal of Australia. 2019;211(8):367–373. doi: 10.5694/mja2.50308. [DOI] [PubMed] [Google Scholar]
- Radke E.G., Glenn B.S., Braun J.M., Cooper G.S. Phthalate exposure and female reproductive and developmental outcomes: A systematic review of the human epidemiological evidence. Environment International. 2019;130:104580. doi: 10.1016/j.envint.2019.02.003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rezniczek G.A., Förster C., Hilal Z., Westhoff T., Tempfer C.B. Calprotectin in pregnancy and pregnancy-associated diseases: A systematic review and prospective cohort study. Archives of Gynecology and Obstetrics. 2019;299(6):1567–1577. doi: 10.1007/s00404-019-05134-8. [DOI] [PubMed] [Google Scholar]
- Rogozińska E., Zamora J., Marlin N., Betrán A.P., Astrup A., Bogaerts, … International Weight Management in Pregnancy (i-WIP) Collaborative Group Gestational weight gain outside the Institute of Medicine recommendations and adverse pregnancy outcomes: Analysis using individual participant data from randomised trials. BioMed Central Pregnancy and Childbirth. 2019;19(1):322. doi: 10.1186/s12884-019-2472-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salomon L.J., Sotiriadis A., Wulff C.B., Odibo A., Akolekar R. Risk of miscarriage following amniocentesis or chorionic villus sampling: Systematic review of literature and updated meta-analysis. Ultrasound in Obstetrics & Gynecology. 2019;54(4):442–451. doi: 10.1002/uog.20353. [DOI] [PubMed] [Google Scholar]
- Shepherd E., Salam R.A., Manhas D., Synnes A., Middleton P., Makrides M., Crowther C.A. Antenatal magnesium sulphate and adverse neonatal outcomes: A systematic review and meta-analysis. PLOS Medicine. 2019;16(12) doi: 10.1371/journal.pmed.1002988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sun M., Yan W., Fang K., Chen D., Liu J., Chen Y.…Xia Y. The correlation between PM2.5 exposure and hypertensive disorders in pregnancy: A meta-analysis. Science of the Total Environment. 2020;703:134985. doi: 10.1016/j.scitotenv.2019.134985. [DOI] [PubMed] [Google Scholar]
- Swift B.E., Shah P.S., Farine D. Sonographic lower uterine segment thickness after prior cesarean section to predict uterine rupture: A systematic review and meta-analysis. Acta Obstetricia Et Gynecologica Scandinavica. 2019;98(7):830–841. doi: 10.1111/aogs.13585. [DOI] [PubMed] [Google Scholar]
- Sznewajs A., Pon E., Matthay K.K. Congenital malformation syndromes associated with peripheral neuroblastic tumors: A systematic review. Pediatric Blood & Cancer. 2019;66(10) doi: 10.1002/pbc.27901. [DOI] [PubMed] [Google Scholar]
- Temkin A., Evans S., Manidis T., Campbell C., Naidenko O.V. Exposure-based assessment and economic valuation of adverse birth outcomes and cancer risk due to nitrate in United States drinking water. Environmental Research. 2019;176:108442. doi: 10.1016/j.envres.2019.04.009. [DOI] [PubMed] [Google Scholar]
- Teulings N.E.W.D., Masconi K.L., Ozanne S.E., Aiken C.E., Wood A.M. Effect of interpregnancy weight change on perinatal outcomes: Systematic review and meta-analysis. BioMed Central Pregnancy and Childbirth. 2019;19(1):386. doi: 10.1186/s12884-019-2566-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Valiton V., Hugon-Rodin J., Fontana P., Neerman-Arbez M., Casini A. Obstetrical and postpartum complications in women with hereditary fibrinogen disorders: A systematic literature review. Haemophilia. 2019;25(5):747–754. doi: 10.1111/hae.13825. [DOI] [PubMed] [Google Scholar]
- Wang Y., Liu S., He L. Prophylactic use of tranexamic acid reduces blood loss and transfusion requirements in patients undergoing cesarean section: A meta-analysis. Journal of Obstetrics and Gynaecology Research. 2019;45(8):1562–1575. doi: 10.1111/jog.14013. [DOI] [PubMed] [Google Scholar]
- Xia Y., Griffiths B.B., Xue Q. Tranexamic acid for postpartum hemorrhage prevention in vaginal delivery: A meta-analysis. Medicine. 2020;99(3) doi: 10.1097/MD.0000000000018792. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Xu Q., Xie Q. Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: A systematic review and meta-analysis. Archives of Gynecology and Obstetrics. 2019;299(5):1295–1303. doi: 10.1007/s00404-019-05124-w. [DOI] [PubMed] [Google Scholar]
- Yin X., Li J., Li Y., Zou S. Maternal alcohol consumption and oral clefts: A meta-analysis. British Journal of Oral & Maxillofacial Surgery. 2019;57(9):839–846. doi: 10.1016/j.bjoms.2019.08.013. [DOI] [PubMed] [Google Scholar]
- Zhang J., Ma S., Wu S., Guo C., Long S., Tan H. Effects of probiotic supplement in pregnant women with gestational diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Journal of Diabetes Research, 2019. 2019:5364730. doi: 10.1155/2019/5364730. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zheng W., Cai D.-B., Zheng W., Sim K., Ungvari G.S., Peng X.-J.…Xiang Y.-T. Brexanolone for postpartum depression: A meta-analysis of randomized controlled studies. Psychiatry Research. 2019;279:83–89. doi: 10.1016/j.psychres.2019.07.006. [DOI] [PubMed] [Google Scholar]
- Zheng Z., Xie G., Yang T., Qin J. Congenital malformations are associated with secondhand smoke among nonsmoking women: A meta-analysis. Birth. 2019;46(2):222–233. doi: 10.1111/birt.12401. [DOI] [PubMed] [Google Scholar]
- Zhong Q., Peng M., He J., Yang W., Huang F. Association of prenatal exposure to phenols and parabens with birth size: A systematic review and meta-analysis. Science of the Total Environment. 2020;703:134720. doi: 10.1016/j.scitotenv.2019.134720. [DOI] [PubMed] [Google Scholar]
Featured Review: Guo, B.-Q., Li, H.-B., Zhai, D.-S., & Ding, S.-B. (2019). Association of maternal prenatal folic acid intake with subsequent risk of autism spectrum disorder in children: A systematic review and meta-analysis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 94, 109650. https://doi.org/10.1016/j.pnpbp.2019.109650
In this meta-analysis, Guo et al. (2019) pooled data from eight observational studies, including a total of 840,776 children of whom 7127 were diagnosed with autism spectrum disorder (ASD). The exposure of interest was folic acid, which, in addition to reducing neural tube defects (Werler et al., 1993), appears to be associated with other beneficial pregnancy outcomes, including childhood neurodevelopment (Hua et al., 2016; McNulty et al., 2019). Numerous researchers have therefore postulated folic acid might also be associated with ASD.
Guo et al. (2019), however, found no association between folic acid and ASD; the pooled estimate from studies reporting odds ratios was 0.91 (95% CI, 0.73–1.13), and the pooled estimate from studies reporting hazard ratios was 0.66 (0.38–1.17). They concluded, “This study does not provide support for the association between maternal FA [folic acid] intake during the prenatal period and the reduced risk of ASD in children.… More investigation is needed” (Guo et al., 2019, p. 12).
Comment: I agree Guo et al.’s (2019) results are compatible with no association between folic acid supplementation and ASD. However, I disagree with their conclusion that more investigations are necessary. It is possible a beneficial effect of folic acid would be observed with more careful assessment of the exposure. Not all of the studies included in this meta-analysis assessed folic acid during the pre-conception period. Perhaps nuancing exactly when the supplements were taken would allow a more precise estimate of any association with ASD.
However, it is fairly clear from looking at Figure 1 in Guo et al.’s (2019) article that folic acid is not harmful, at least in terms of ASD. Given the current recommendations concerning folic acid for women of childbearing age, I would argue it does not matter whether folic acid might also prevent ASD. Folic acid is known to prevent neural tube defects, and on the basis of that knowledge, we supplement our food supply and encourage women to take folic acid before and during pregnancy. This clinical message would not change if folic acid also prevents ASD. Thus, in my opinion, we do not need more studies on this topic. Completed studies combine to indicate no association, and, even if there was one, we would not change practice.
References
Guo, B.-Q., Li, H.-B., Zhai, D.-S., & Ding, S.-B. (2019). Association of maternal prenatal folic acid intake with subsequent risk of autism spectrum disorder in children: A systematic review and meta-analysis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 94, 109650. https://doi.org/10.1016/j.pnpbp.2019.109650
Hua, X., Zhang, J., Guo, Y., Shen, M., Gaudet, L., Janoudi, G., … Wen, S. W. (2016). Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis. Hypertension in Pregnancy, 35(4), 447–460. https://doi.org/10.1080/10641955.2016.1183673
McNulty, H., Rollins, M., Cassidy, T., Caffrey, A., Marshall, B., Dornan, J., … Pentieva, K. (2019). Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: A follow-up study from a randomized controlled trial (FASSTT Offspring Trial). BioMed Central Medicine, 17(1), 196. https://doi.org/10.1186/s12916-019-1432-4
Werler, M. M., Shapiro, S., & Mitchell, A. A. (1993). Periconceptional folic acid exposure and risk of occurrent neural tube defects. Journal of the American Medical Association, 269(10), 1257–1261. https://doi.org/10.1001/jama.1993.03500100055027
Featured Review: Cuningham, W., Geard, N., Fielding, J. E., Braat, S., Madhi, S. A., Nunes, M. C., … Moss, R. (2019). Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis. Influenza and Other Respiratory Viruses, 13(5), 438–452. https://doi.org/10.1111/irv.12649
In this meta-analysis, Cuningham et al. (2019) summarized the results from 16 studies on timing of influenza vaccine during pregnancy, spanning eight countries and eight influenza seasons. The studies varied in design, and researchers compared immunologic responses of women vaccinated in the first, second, or third trimesters; none included confirmed or suspected influenza illness as an outcome. The authors of the meta-analysis concluded third trimester inoculation induces a greater immune response.
Comment: I do not think this conclusion is supported by the data. Based on data displayed in the meta-analysis (specifically, Figures 1–3), there does not appear to be a clinically-relevant difference in immune response for women vaccinated in the third trimester compared to the other trimesters (Cuningham et al., 2019). Indeed, there does not seem to be much of a difference at all. Furthermore, realistically, in clinical practice during flu season, we would vaccinate women when we see them, regardless of gestational age. If a woman presented in January for antenatal care at 14 weeks gestation, she would be sent for a flu shot if she had not already had one that season. Likewise it would not be ethical to tell a 20-week pregnant woman in October that she must wait until December to get vaccinated because that would be her third trimester.
Cunningham et al. (2019) make a legitimate attempt to adjust for seasonality, but this is nearly impossible to tease out given the nature of the data and durations of pregnancies and flu seasons. I also find it problematic that none of the researchers in the included studies looked at the actual end-point: influenza infection. Immune response is at best a proxy for this, and proxy (surrogate) outcomes are always suspect (Alonso et al., 2015, Bovbjerg et al., 2019, Buyse et al., 2016, Gomella and Oliver Sartor, 2014, Patel et al., 2016, Schievink et al., 2014). Given that pregnancy is known to induce alterations in one’s immune system (Blackburn, 2003), how valid it is to compare antibody titers across trimesters?
Finally, I would like to raise a related idea: immortal time bias (Hutcheon & Savitz, 2016). This epidemiological concept must always be considered when studying pregnancy, particularly when preterm birth (or gestational age more generally) is the outcome. Immortal time bias can arise when you have a one-time exposure and a time-variant outcome. For instance, if we did a study on whether flu vaccines during pregnancy were associated with preterm birth, we would run into trouble because women who gave birth preterm had a shorter window during which they could have been exposed to having a flu shot. Thus, we could easily find influenza vaccination is protective because fewer women who gave birth preterm had one. However, it is not that the vaccine itself actually reduces the preterm risk; rather, women who remained pregnant then had another several weeks during which they might have gotten the flu shot. Studying flu vaccination during pregnancy is then made even more complex because of seasonality. Bottom line: all of us should get flu shots, including pregnant women.
References
- Alonso A., Van der Elst W., Molenberghs G., Buyse M., Burzykowski T. On the relationship between the causal-inference and meta-analytic paradigms for the validation of surrogate endpoints. Biometrics. 2015;71(1):15–24. doi: 10.1111/biom.12245. [DOI] [PubMed] [Google Scholar]
- Blackburn S.T. 2nd ed. Saunders; 2003. Maternal, Fetal, & Neonatal Physiology: A Clinical Perspective. [Google Scholar]
- Bovbjerg M.L., Dissanayake M., Brown J., Cheyney M., Snowden J.M. Utility of the 5-minute Apgar score as a research end point. American Journal of Epidemiology. 2019;188(9):1695–1704. doi: 10.1093/aje/kwz132. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Buyse M., Molenberghs G., Paoletti X., Oba K., Alonso A., Van der Elst W., Burzykowski T. Statistical evaluation of surrogate endpoints with examples from cancer clinical trials. Biometrical Journal. 2016;58(1):104–132. doi: 10.1002/bimj.201400049. [DOI] [PubMed] [Google Scholar]
- Cuningham W., Geard N., Fielding J.E., Braat S., Madhi S.A., Nunes M.C.…Moss R. Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis. Influenza and Other Respiratory Viruses. 2019;13(5):438–452. doi: 10.1111/irv.12649. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gomella L.G., Oliver Sartor A. The current role and limitations of surrogate endpoints in advanced prostate cancer. Urologic Oncology. 2014;32(1) doi: 10.1016/j.urolonc.2012.10.001. 28.e1-9. [DOI] [PubMed] [Google Scholar]
- Hutcheon J.A., Savitz D.A. Invited commentary: Influenza, influenza immunization, and pregnancy-it’s about time. American Journal of Epidemiology. 2016;184(3):187–191. doi: 10.1093/aje/kww042. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Patel R.B., Vaduganathan M., Samman-Tahhan A., Kalogeropoulos A.P., Georgiopoulou V.V., Fonarow G.C.…Butler J. Trends in utilization of surrogate endpoints in contemporary cardiovascular clinical trials. American Journal of Cardiology. 2016;117(11):1845–1850. doi: 10.1016/j.amjcard.2016.03.021. [DOI] [PubMed] [Google Scholar]
- Schievink B., Lambers Heerspink H., Leufkens H., De Zeeuw D., Hoekman J. The use of surrogate endpoints in regulating medicines for cardio-renal disease: Opinions of stakeholders. PLOS ONE. 2014;9(9) doi: 10.1371/journal.pone.0108722. [DOI] [PMC free article] [PubMed] [Google Scholar]
Recent Evidence-Based Reviews: Infant Health and Breastfeeding
- Abdelhakim A.M., Sunoqrot M., Amin A.H., Nabil H., Raslan A.N., Samy A. The effect of early vs. delayed postpartum insertion of the LNG-IUS on breastfeeding continuation: A systematic review and meta-analysis of randomised controlled trials. European Journal of Contraception & Reproductive Health Care. 2019;24(5):327–336. doi: 10.1080/13625187.2019.1665175. [DOI] [PubMed] [Google Scholar]
- Bhatt G.C., Gogia P., Bitzan M., Das R.R. Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: A systematic review. Archives of Disease in Childhood. 2019;104(7):670–679. doi: 10.1136/archdischild-2018-315805. [DOI] [PubMed] [Google Scholar]
- Fleeman N., Dundar Y., Shah P.S., Shaw B.N. Heated humidified high-flow nasal cannula for preterm infants: An updated systematic review and meta-analysis. International Journal of Technology Assessment in Health Care. 2019;35(4):298–306. doi: 10.1017/S0266462319000424. [DOI] [PubMed] [Google Scholar]
- Garrison M.P., Maisano P. Systematic review of factors influencing non-medically indicated formula supplementation of newborns in the hospital setting. Nursing for Women’s Health. 2019;23(4):340–350. doi: 10.1016/j.nwh.2019.06.003. [DOI] [PubMed] [Google Scholar]
- Kariholu U., Montaldo P., Markati T., Lally P.J., Pryce R., Teiserskas J.…Thayyil S. Therapeutic hypothermia for mild neonatal encephalopathy: A systematic review and meta-analysis. Archives of Disease in Childhood. Fetal and Neonatal Edition. 2020;105(2):225–228. doi: 10.1136/archdischild-2018-315711. [DOI] [PubMed] [Google Scholar]
- Kołodziej M., Patro-Gołąb B., Gieruszczak-Białek D., Skórka A., Pieścik-Lech M., Baron R.…on behalf of the SAWANTI Working Group Association between early life (prenatal and postnatal) antibiotic administration and coeliac disease: A systematic review. Archives of Disease in Childhood. 2019;104(11):1083–1089. doi: 10.1136/archdischild-2019-317174. [DOI] [PubMed] [Google Scholar]
- MacVicar S., Kelly L.E. Systematic mixed-study review of nonpharmacological management of neonatal abstinence syndrome. Birth. 2019;46(3):428–438. doi: 10.1111/birt.12427. [DOI] [PubMed] [Google Scholar]
- McCarthy E.K., Dempsey E.M., Kiely M.E. Iron supplementation in preterm and low-birth-weight infants: A systematic review of intervention studies. Nutrition Reviews. 2019;77(12):865–877. doi: 10.1093/nutrit/nuz051. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parri N., Trippella G., Lisi C., De Martino M., Galli L., Chiappini E. Accuracy of presepsin in neonatal sepsis: Systematic review and meta-analysis. Expert Review of Anti-Infective Therapy. 2019;17(4):223–232. doi: 10.1080/14787210.2019.1584037. [DOI] [PubMed] [Google Scholar]
- Patro-Gołąb B., Zalewski B.M., Polaczek A., Szajewska H. Duration of breastfeeding and early growth: A systematic review of current evidence. Breastfeeding Medicine. 2019;14(4):218–229. doi: 10.1089/bfm.2018.0187. [DOI] [PubMed] [Google Scholar]
- Stadler J., Raith W., Mileder L.P., Schmölzer G.M., Urlesberger B. Invasive and non-invasive acupuncture techniques for pain management in neonates: A systematic review. Acupuncture in Medicine. 2019;37(4):201–210. doi: 10.1136/acupmed-2017-011549. [DOI] [PubMed] [Google Scholar]
Recent Evidence-Based Reviews: Nursing Education and Practice
- Huang J., Tang Y., Tang J., Shi J., Wang H., Xiong T.…Mu D. Educational efficacy of high-fidelity simulation in neonatal resuscitation training: A systematic review and meta-analysis. BioMed Central Medical Education. 2019;19(1):323. doi: 10.1186/s12909-019-1763-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morris M., Cooper R.L., Ramesh A., Tabatabai M., Arcury T.A., Shinn M.…Matthews-Juarez P. Training to reduce LGBTQ-related bias among medical, nursing, and dental students and providers: A systematic review. BioMed Central Medical Education. 2019;19(1):325. doi: 10.1186/s12909-019-1727-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ouyang M., Peng K., Botfield J.R., McGeechan K. Intrauterine contraceptive device training and outcomes for healthcare providers in developed countries: A systematic review. PLOS ONE. 2019;14(7) doi: 10.1371/journal.pone.0219746. [DOI] [PMC free article] [PubMed] [Google Scholar]
