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. 2019 Nov 19;69(7):1283–1293. doi: 10.1136/gutjnl-2019-319438

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Transcriptome heterogeneity of lesions at different evolutionary stages from FAP1. (A) Clustering analysis of all epithelial cells from FAP1 by using tSNE. Four clusterswere identified (top) and the tissue origin for each single cell was indicated (bottom). (B) Heatmap showing the specifically highly expressed genes in each cluster. (C) GO analysis of genes highly expressed in cluster 3. (D) Immumohistochemical staining of CD8 in four regions of carcinomas from FAP1. Scale bar, 100 µm. (E) GO analysis of genes highly expressed in cluster 4. Car, carcinoma; Ade, adenoms; FAP, familial adenomatous polyposis; GO, gene ontology; MAPK, mitogen-activated protein kinase.