Table 1.
Quantitative histologic analysis at +1.08, −1.60, and −3.60 mm from bregma
| Level +1.08 mm | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| t test | Ipsilateral | Contralateral | |||||||
| AI | CD (×10−2 cell/μm2) | AI | CD (×10−2 cell/μm2) | ||||||
| Mean ± SD | t(AI) | Mean ± SD | t(CD) | Mean ± SD | t(AI) | Mean ± SD | t(CD) | ||
| cc | Sham | 0.81 ± 0.05 | 0.61 | 0.53 ± 0.03 | 0.41 | 0.80 ± 0.04 | 0.51 | 0.52 ± 0.04 | 0.38 |
| mTBI | 0.83 ± 0.03 | 0.52 ± 0.04 | 0.81 ± 0.03 | 0.52 ± 0.02 | |||||
| ec | Sham | 0.73 ± 0.04 | 0.94 | 0.43 ± 0.03 | 0.62 | 0.75 ± 0.03 | 0.25 | 0.44 ± 0.05 | 0.47 |
| mTBI | 0.71 ± 0.04 | 0.44 ± 0.04 | 0.75 ± 0.03 | 0.46 ± 0.05 | |||||
| S1 | Sham | 0.43 ± 0.06 | 1.06 | 0.39 ± 0.02 | 0.56 | 0.47 ± 0.04 | 0.11 | 0.39 ± 0.01 | 0.80 |
| mTBI | 0.47 ± 0.06 | 0.40 ± 0.06 | 0.47 ± 0.01 | 0.38 ± 0.03 | |||||
| Level –1.60 mm | |||||||||
| cc | Sham | 0.85 ± 0.02 | 2.06 | 0.51 ± 0.05 | 1.46 | 0.84 ± 0.04 | 0.04 | 0.50 ± 0.02 | 1.89 |
| mTBI | 0.82 ± 0.04 | 0.55 ± 0.04 | 0.82 ± 0.03 | 0.53 ± 0.03 | |||||
| ec | Sham | 0.71 ± 0.06 | 1.91 | 0.43 ± 0.04 | 2.91 | 0.73 ± 0.02 | 0.51 | 0.42 ± 0.03 | 1.22 |
| mTBI | 0.66 ± 0.03 | 0.50 ± 0.05 | 0.72 ± 0.05 | 0.44 ± 0.04 | |||||
| S1 | Sham | 0.38 ± 0.05 | 0.23 | 0.39 ± 0.02 | 1.18 | 0.45 ± 0.05 | 0.52 | 0.39 ± 0.02 | 0.45 |
| mTBI | 0.38 ± 0.06 | 0.41 ± 0.03 | 0.44 ± 0.05 | 0.39 ± 0.02 | |||||
| Level –3.60 mm | |||||||||
| cc | Sham | 0.83 ± 0.04 | 1.18 | 0.50 ± 0.06 | 0.50 | 0.80 ± 0.06 | 1.25 | 0.49 ± 0.03 | 0.37 |
| mTBI | 0.78 ± 0.05 | 0.52 ± 0.06 | 0.75 ± 0.07 | 0.50 ± 0.06 | |||||
| ec | Sham | 0.76 ± 0.03 | 4.97 | 0.44 ± 0.03 | 4.71 | 0.73 ± 0.04 | 2.44 | 0.43 ± 0.03 | 0.47 |
| mTBI | 0.60 ± 0.08* | 0.56 ± 0.06* | 0.78 ± 0.03 | 0.42 ± 0.03 | |||||
| S1 | Sham | 0.34 ± 0.07 | 1.40 | 0.39 ± 0.02 | 4.01 | 0.35 ± 0.09 | 0.63 | 0.39 ± 0.03 | 1.04 |
| mTBI | 0.30 ± 0.05 | 0.46 ± 0.05* | 0.33 ± 0.04 | 0.38 ± 0.01 | |||||
| ic | Sham | 0.53 ± 0.09 | 1.40 | 0.38 ± 0.03 | 4.23 | 0.56 ± 0.08 | 0.23 | 0.38 ± 0.02 | 1.19 |
| mTBI | 0.47 ± 0.04 | 0.45 ± 0.02* | 0.57 ± 0.04 | 0.35 ± 0.04 | |||||
| VPL | Sham | 0.43 ± 0.03 | 0.49 | 0.33 ± 0.03 | 3.08 | 0.45 ± 0.05 | 0.28 | 0.33 ± 0.03 | 0.30 |
| mTBI | 0.43 ± 0.03 | 0.38 ± 0.04 | 0.44 ± 0.04 | 0.34 ± 0.03 | |||||
Statistically significant FDR-corrected q values are shown (* q < 0.05 corresponding to uncorrected * p < 3.10 × 10−3; unpaired t test) for the anisotropy index (AI) and CD (×10−2 cell/μm2). AI, anisotropy index; cc, corpus callosum; CD, cell density; ec, external capsule; ic, internal capsule; S1, somatosensory cortex; VPL, ventral posterolateral thalamic nucleus.