Table 2.
Multiple linear regression between quantitative DTI and histologic analysis at +1.08, −1.60, and −3.60 mm from bregma
| Level +1.08 mm | ||||||||
|---|---|---|---|---|---|---|---|---|
| FA | AD (×10–3 mm2/s) | |||||||
| R² adj | F stat | t(AI) | t(CD) | R² adj | F stat | t(AI) | t(CD) | |
| cc | 0.02 | 1.24 | –1.42 | 0.14 | 0 | 0.46 | –0.20 | –0.94 |
| ec | 0.11 | 2.64 | 1.38 | 1.88 | 0.15 | 3.45 | 2.58* | 0.58 |
| S1 | 0.01 | 1.09 | –0.11 | 1.47 | 0 | 0.15 | –0.16 | –0.48 |
| cc + ec | 0.68*** | 60.0 | 5.10*** | 6.28*** | 0.66*** | 55.1 | 6.34*** | 4.53*** |
| Level –1.60 mm | ||||||||
| cc | 0.51*** | 14.8 | 1.49 | –4.97*** | 0.09 | 2.25 | –0.42 | –2.12 |
| ec | 0.08 | 2.14 | 0.14 | –1.94 | 0.25* | 5.52 | 2.08 | –1.87 |
| S1 | 0 | 0.40 | 0.66 | –0.55 | 0.05 | 1.65 | –0.98 | –1.60 |
| cc + ec | 0.33*** | 14.5 | 5.39*** | –2.40 | 0.55*** | 34.3 | 7.54*** | –0.28 |
| Level –3.60 mm | ||||||||
| cc | 0.20 | 4.29 | 2.91* | –0.78 | 0 | 0.87 | 1.17 | –0.79 |
| ec | 0.72*** | 35.4 | 3.00* | –2.37 | 0.69*** | 31.4 | 4.54*** | –0.32 |
| S1 | 0.08 | 2.19 | –0.35 | –2.06 | 0.03 | 1.47 | –0.36 | 0.10 |
| ic | 0.23* | 4.95 | 1.98 | –1.51 | 0.33** | 7.76 | 3.72** | 0.19 |
| VPL | 0.15 | 3.37 | –1.96 | –2.03 | 0 | 0.59 | 0.28 | –0.98 |
| cc + ec | 0.53*** | 32.0 | 5.02*** | –4.63*** | 0.48*** | 26.5 | 5.45*** | –3.17** |
| cc + ec + ic | 0.51*** | 44.2 | –1.09 | –8.52*** | 0.33*** | 21.6 | 5.44*** | –5.23*** |
| S1 + VPL | 0.39*** | 18.6 | –5.12*** | –0.33 | 0.14* | 5.48 | –2.95* | –0.52 |
Statistically significant FDR-corrected q values are shown (*q < 0.05; **q < 0.01; ***q < 0.001 corresponding to uncorrected *p < 1.97 × 10−2, **p < 2.5 × 10−3, ***p < 1.22 × 10−4, respectively; multiple linear regression test) for the AI, CD (×10−2 cell/μm2), and both parameters. AD, axial diffusivity; AI, anisotropy index; cc, corpus callosum; CD, cell density; ec, external capsule; FA, fractional anisotropy; ic, internal capsule; S1, somatosensory cortex; VPL, ventral posterolateral thalamic nucleus.